StackTerminal.Health

BETA

Bitter Orange (Synephrine)

Bitter Orange, containing p-synephrine, is a stimulant that increases metabolic rate and lipolysis, often used for weight management and fat loss. It is considered to have a lower cardiovascular impact compared to ephedrine.

fat-lossmetabolismstimulantweight-management
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood PressureResting Heart Rate
Metabolic
Body Weight
Evidence
5 records
Weight loss
Adults seeking weight managementMeta-analysis
PUBMEDHigh

The meta-analysis found that p-synephrine can promote weight loss with minimal cardiovascular side effects.

Dose: 50 mg
Resting energy expenditure
AdultsRCT
PUBMEDModerate

Acute ingestion of p-synephrine increased resting energy expenditure.

Dose: 50 mgDuration: AcuteTiming: Pre-exercise
Cardiovascular safety
Healthy subjectsRCT
PUBMEDModerate

A single dose of bitter orange extract did not prolong QTc interval or cause significant hemodynamic effects.

Dose: 50 mgDuration: Single doseTiming: Single dose
Fat oxidation during exercise
Healthy active womenRCT
PUBMEDModerate

p-Synephrine increased fat oxidation rate during exercise of increasing intensity.

Dose: 50 mgDuration: AcuteTiming: During exercise
Fat oxidation at rest
AdultsRCT
PUBMEDModerate

p-Synephrine increased fat oxidation at rest.

Dose: 50 mgDuration: AcuteTiming: At rest
Forms
Extract
Standardized for p-synephrine content
Capsule
Convenient for dosing
Powder
Can be mixed with liquids

Stacks containing Bitter Orange (Synephrine)

Public community stacks that include this ingredient.

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metabolicweight-managementfat-loss

Combining Bitter Orange with Grains of Paradise can enhance metabolic rate and support weight management. Bitter Orange is a stimulant that increases metabolic rate, while Grains of Paradise promotes fat loss by increasing energy expenditure.

Bitter Orange (Synephrine)
50mg
Grains of Paradise (Paradoxine)
40mg
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