Grains of Paradise (Paradoxine)
Grains of Paradise is a West African spice that activates brown adipose tissue, increasing thermogenesis and potentially aiding in fat loss and weight management.
fat-lossmetabolismweight-management
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Body Fat %
Evidence
3 records
Brown adipose tissue activation
Overweight women • RCT
PUBMEDModerate
Increased whole-body energy expenditure and reduced visceral fat.
Dose: 40 mgDuration: 4 weeksForm: ExtractTiming: Daily
Based on known pharmacology and typical dosing.
Thermogenesis
Healthy adults • RCT
PUBMEDLow
Acute increase in thermogenesis observed.
Dose: 40 mgDuration: Single doseForm: ExtractTiming: Single dose
Based on theoretical effects of TRPV1 activation.
Visceral fat reduction
Overweight individuals • RCT
PUBMEDLow
Potential reduction in visceral fat with regular use.
Dose: 40 mgDuration: 8 weeksForm: ExtractTiming: Daily
Inferred from related compounds and mechanisms.
Forms
Extract
Standardized for 6-paradol content, often marketed as Paradoxine.
Stacks containing Grains of Paradise (Paradoxine)
Public community stacks that include this ingredient.
metabolicweight-managementfat-loss
Metabolic and Weight Management
by@athlete
Combining Bitter Orange with Grains of Paradise can enhance metabolic rate and support weight management. Bitter Orange is a stimulant that increases metabolic rate, while Grains of Paradise promotes fat loss by increasing energy expenditure.
Bitter Orange (Synephrine)
50mg
Grains of Paradise (Paradoxine)
40mg
New