Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.
Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.
SpirulinaModerateDaily (any time) • Spirulina powder or tablets • Reduced oxidative stress & improved time-to-exhaustion in several trials; effect sizes modest.6000mg
Contamination risk (heavy metals, cyanotoxins) from non-certified sources — always buy third-party tested
Iodine content may affect thyroid function — caution with thyroid disorders or thyroid medication
Mild blood-thinning activity — caution when combined with anticoagulants
Reduced oxidative stress & improved time-to-exhaustion in several trials; effect sizes modest.
Urolithin AModerateDaily (any time) • Urolithin A (Mitopure) • Improved handgrip & leg muscle endurance; mitophagy markers improved; good safety profile.500mg
Limited long-term human safety data — trials up to 4 months only
Improved handgrip & leg muscle endurance; mitophagy markers improved; good safety profile.
Fish OilHighWith food • Triglyceride fish oil • Dose-dependent triglyceride reduction; anti-inflammatory signals; cardiovascular outcome benefit at high doses in high-risk groups.2000mg
Fishy aftertaste/burps — take with a fat-containing meal or use enteric-coated softgels
Mild anticoagulant effect — caution pre-surgery or when combined with blood thinners
Context: doses >3g EPA+DHA/day
Oxidised fish oil from low-quality products may be pro-inflammatory — choose products with TOTOX testing certification
Dose-dependent triglyceride reduction; anti-inflammatory signals; cardiovascular outcome benefit at high doses in high-risk groups.
Collagen PeptidesModerateDaily (any time) • Type I/III hydrolysed collagen peptides • Reduces activity-related joint pain; when taken pre-exercise with vitamin C, promotes tendon collagen synthesis.10000mg
Incomplete amino acid profile — not a substitute for complete protein sources
Marine collagen carries shellfish allergy risk — use bovine or plant-derived if allergic
Some products contain heavy metals — prioritise third-party tested sources
Reduces activity-related joint pain; when taken pre-exercise with vitamin C, promotes tendon collagen synthesis.
During training or after sweating • Electrolyte powder / tablet • Sodium supplementation prevents hyponatraemia in prolonged exercise; maintains fluid balance & reduces cramping.500mg
Excess sodium can raise blood pressure — monitor if hypertensive or on a sodium-restricted diet
Potassium supplementation interacts with ACE inhibitors and potassium-sparing diuretics — risk of dangerous hyperkalaemia
Sodium supplementation prevents hyponatraemia in prolonged exercise; maintains fluid balance & reduces cramping.
Discussion
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