Metformin
Metformin is a biguanide antidiabetic medication primarily used to control blood glucose levels in individuals with type 2 diabetes. It is also being studied for its potential benefits in longevity, cancer prevention, & metabolic syndrome.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Metformin has strong evidence for blood glucose control in type 2 diabetes and moderate evidence for reducing cancer incidence and aiding weight management. However, its use should be carefully monitored due to potential gastrointestinal side effects.
Blood glucose controlPatients with type 2 diabetes · Systematic reviewHigh
Metformin is effective in controlling blood glucose levels in patients with type 2 diabetes.
Insulin sensitivityWomen with polycystic ovary syndrome (PCOS) · Systematic reviewModerate
Metformin is widely used to treat insulin resistance in PCOS, although it may cause gastrointestinal side effects.
Weight managementPatients with obesity · Systematic reviewModerate
Metformin has been shown to aid in weight management in patients with obesity.
Cancer incidenceGeneral population · Systematic reviewModerate
Metformin use is associated with a reduced incidence of cancer.
All-cause mortalityPatients with type 2 diabetes · Systematic reviewModerate
Metformin reduces all-cause mortality & diseases of aging independent of its effect on diabetes control.
Metabolic Health & Weight Management
Metformin & intermittent fasting are combined to support metabolic health & weight management. Metformin improves insulin sensitivity & glucose metabolism, while intermittent fasting aids in weight management & metabolic regulation.