Metabolic & Weight Management

Public • 06 Apr 2026

Bitter melon & gymnema sylvestre are combined to support metabolic health & weight management. Bitter melon helps regulate blood sugar levels, while gymnema sylvestre reduces sugar cravings & supports glucose metabolism.

← Back

Buy stack

metabolic weight-management blood-sugar

Bitter Melon

With meals

MODERATE

1000mg

Gymnema Sylvestre

With meals

MODERATE

300mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

AI risk assessment

Context: No wearable data

PROAI risk assessment is available with Pro.

See plans

Stack pre-check

No personal data connected — connect wearables or upload bloodwork for a personalised check

Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

No interactions detected

No known absorption conflicts, pharmacokinetic conflicts, or synergies found between the ingredients in this stack.

Supplements

2 items

Bitter MelonModerate

With meals •

Helps regulate blood sugar levels.

Buy ingredient →

1000mg

blood-glucose

Moderate

Population: patients with type 2 diabetes

Study type: RCT

Dose context: 1000 mg typical (range: 1000–2000 mg) • Duration: 12 weeks

Bitter melon significantly lowered fasting glucose levels compared to placebo.

Citation: Amini et al. (2024). The Effects of Bitter Melon (Mormordica charantia) on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal.•DOI: 10.1002/ptr.8357

lipid-profile

Moderate

Population: adults with dyslipidemia

Study type: Systematic review

Dose context: 1000 mg typical

Bitter melon consumption resulted in a significant decrease in plasma triglycerides & LDL cholesterol.

Citation: Guarneiri et al. (2025). Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes. Journal.•DOI: 10.1080/27697061.2024.2428301

blood-glucose

Low

Population: patients with type 2 diabetes

Study type: Review

Dose context: 1000 mg typical

Bitter melon has a moderate hypoglycemic effect, though studies were small & not randomized.

Citation: Leung et al. (2009). Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review. Journal.•DOI: 10.1017/S0007114509992054

Gymnema SylvestreModerate

With meals •

Reduces sugar cravings & supports glucose metabolism.

Buy ingredient →

300mg

body weight

Moderate

Population: obese patients

Study type: Randomized Study

Dose context: 400 mg typical • Duration: 3 months

Gymnema Sylvestre decreased body weight & improved metabolic parameters.

Citation: Bandala et al. (2024). Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study. Journal.•DOI: 10.3390/nu16142284

lipid profile

Moderate

Population: adults

Study type: Systematic review

Dose context: 400 mg typical

Gymnema Sylvestre supplementation may improve lipid profiles.

Citation: Zamani et al. (2023). The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis. Journal.•DOI: 10.1002/ptr.7585

insulin sensitivity

Moderate

Population: patients with impaired glucose tolerance

Study type: RCT

Dose context: 600 mg typical (range: 600–600 mg) • Duration: 12 weeks

Gymnema Sylvestre improved insulin sensitivity & secretion.

Citation: Gaytán Martínez et al. (2021). Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance. Journal.•DOI: 10.26355/eurrev_202203_28360

My experience with this stack

Share what worked, what did not, & help improve this protocol.

Discussion

No comments yet. Be the first to add context or ask a question.

Max 500 characters

Similar community stacks

Avoid reinventing the wheel: fork a community stack that matches your category tags, then edit it.

Browse all community stacks →

metabolicweight-managementblood-sugar

Metabolic Health & Weight Management

by@athlete

Metformin & intermittent fasting are combined to support metabolic health & weight management. Metformin improves insulin sensitivity & glucose metabolism, while intermittent fasting aids in weight management & metabolic regulation.

Metformin

500mg

Intermittent Fasting

0mg

New

View

metabolicweight-lossclinical-only