StackTerminal.Health

BETA

Methylene Blue

Methylene Blue is a phenothiazine dye that acts as a mitochondrial electron shuttle, with preliminary evidence suggesting potential benefits for cognitive enhancement, neuroprotection, & antimicrobial properties.

cognitivemitochondrialneuroprotectionanti-aging
Evidence last reviewed: 05 Apr 2026
Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Cognitive FunctionNeuroprotection / NGF
Evidence
5 records
Hospital length of stay
Patients with septic shockSystematic review
PUBMEDLow

Methylene Blue may reduce hospital length of stay in patients with septic shock.

Dose: 2 mg
Cognitive enhancement
General populationTheoretical
PUBMEDVery low

Methylene Blue is theorized to enhance cognitive function through its role as a mitochondrial electron shuttle.

Dose: 2 mgForm: Oral
No direct clinical evidence available.
Neuroprotection
General populationTheoretical
PUBMEDVery low

Methylene Blue is theorized to offer neuroprotective benefits due to its antioxidant properties.

Dose: 2 mgForm: Oral
No direct clinical evidence available.
Vasopressor discontinuation time
Patients with septic shockMeta-analysis
PUBMEDLow

Methylene Blue may reduce the time to vasopressor discontinuation & increase vasopressor-free days.

Dose: 2 mg
Mortality reduction
Critically ill and perioperative patientsMeta-analysis
PUBMEDLow

Methylene Blue may reduce mortality in critically ill & perioperative patients.

Dose: 2 mg
Forms
Oral
Commonly used for cognitive and neuroprotective purposes.
Intravenous
Used in clinical settings for conditions like septic shock.

Stacks containing Methylene Blue

Public community stacks that include this ingredient.

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cognitiveneuroprotectionfocus

Pyrroloquinoline quinone (PQQ) & methylene blue are combined to support cognitive function & provide neuroprotection. PQQ supports mitochondrial function & cognitive performance, while methylene blue enhances mitochondrial function & provides neuroprotective benefits.

Pyrroloquinoline Quinone (PQQ)
20mg
Methylene Blue
2mg
New
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cognitiveenergyfocus

Modafinil & methylene blue are combined to enhance cognitive function & energy levels. Modafinil is a wakefulness-promoting agent that improves focus, while methylene blue supports mitochondrial function & cognitive performance.

Modafinil
100mg
Methylene Blue
2mg
New
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