StackTerminal.Health

BETA

L-Citrulline Malate

Precursor to arginine & nitric oxide; used to support blood flow, reduce fatigue, & improve exercise performance.

performanceendurancepumpcardio
Evidence last reviewed: 04 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
VO₂ MaxBlood Pressure
Performance
Aerobic Capacity
Evidence
3 records
Aerobic exercise performance / oxygen kinetics / RPE
Recreationally active and trained adultsSystematic review & meta-analysis
PUBMEDModerate

Positive impact on aerobic performance outcomes including lactate, VO2 kinetics, & perceived exertion via nitric oxide-mediated vasodilation; results mixed, effect sizes small.

Dose: 6000 mgDuration: Acute to 7 days
Ergogenic effects more consistent for resistance than large-muscle endurance tasks.
Systolic blood pressure reduction
Adults; mixed health status (8 trials)Systematic review & meta-analysis
PUBMEDModerate

Pooled reduction of −4.1 mmHg systolic BP (95% CI −7.94 to −0.26); diastolic reduction significant only at ≥6 g/day.

Dose: 6000 mgDuration: 1–17 weeks
Antihypertensive effect modest; most consistent with doses ≥6 g/day.
Resistance exercise repetitions to failure
Resistance-trained adultsSystematic review & meta-analysis
PUBMEDModerate

Significant benefit for total repetitions to failure vs. placebo (SMD = 0.20, p = 0.036) with citrulline malate; 8 g acutely prior to upper/lower body resistance exercise.

Dose: 8000 mgDuration: Acute (single dose pre-exercise)Form: MalateTiming: pre-exercise
Pérez-Guisado & Jakeman 2010 RCT (PMID 20386132) found ~52% more bench press reps with 8 g CM vs. placebo.
Forms
Citrulline malate (2:1)
Most common form in sports research; 8 g CM ≈ 5 g L-citrulline.
L-citrulline (pure)
Higher citrulline content per gram.

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