L-Citrulline
L-Citrulline is a non-essential amino acid that enhances nitric oxide production, which can improve blood flow, reduce muscle soreness, & boost endurance performance, particularly in athletes.
Evidence last reviewed: 05 Apr 2026
L-Citrulline is an amino acid that may enhance blood flow and endurance, particularly in athletes. While some studies show benefits, results can vary across different populations.
Summarized study outcomes with population, design, grade, and effect data.
The evidence for L-Citrulline shows moderate benefits for endurance performance and blood pressure reduction, particularly in specific populations. However, some studies indicate no significant effects on exercise performance in the general population, highlighting the need for more targeted research.
Cardiovascular healthGeneral population · Systematic review and meta-analysisModerate
L-Citrulline showed moderate evidence for reducing cardiovascular risk factors.
Endurance performanceYoung adult trained males · RCTModerate
L-Citrulline supplementation showed potential benefits for endurance performance.
Exercise performanceGeneral population · Systematic review and meta-analysisLow
No significant effect on exercise performance was found following L-citrulline supplementation.
Blood pressureHypertensive postmenopausal women · Systematic reviewModerate
L-Citrulline supplementation improved endothelial function & reduced blood pressure.
Blood pressureMiddle-aged and older adults · Systematic review and meta-analysisModerate
L-Citrulline supplementation was associated with reduced blood pressure.
Stacks containing L-Citrulline
Public community stacks that include this ingredient.
Athletic Performance and Recovery
Combining L-Citrulline with Electrolytes can enhance athletic performance and support recovery. L-Citrulline improves nitric oxide production and endurance, while Electrolytes support hydration and muscle function.
Athletic Performance Enhancement
Betaine anhydrous & l-citrulline are combined to enhance athletic performance & endurance. Betaine anhydrous supports strength & power, while l-citrulline aids in nitric oxide production, improving blood flow & endurance.