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BETA

Sodium Citrate

Alkalizing electrolyte salt used as a pre-exercise buffer to attenuate exercise-induced acidosis during high-intensity efforts.

electrolytes

Evidence last reviewed: 04 Apr 2026

Evidence
2 records
2 recordsBest grade:Low
Biomarkers
Time to Exhaustion

The evidence suggests sodium citrate can improve time to exhaustion in trained cyclists and reliably induce blood alkalosis, which may enhance performance. However, the overall strength of the evidence is low, and more robust studies are needed to confirm its benefits.

Blood alkalosis induction & exercise performance during high-intensity exercise
Trained athletes performing high-intensity and supramaximal exercise · Narrative review of RCTs and physiological studies
Low

Sodium citrate at 500 mg/kg body mass in capsule form reliably induces blood alkalosis & is most beneficial for short-duration, very high-intensity exercise; only 25% of observations showed significant performance improvements in high-intensity intermittent exercise, & gastrointestinal symptoms are a key limiting factor.

Dose: Form: Citrate
Capsule administration preferred over liquid to reduce GI distress.
Performance during supramaximal cycling (time to exhaustion)
Trained male cyclists · Randomized crossover trial
Low

Sodium citrate ingestion significantly increased time to exhaustion during supramaximal cycling exercise versus placebo, associated with reduced intramuscular acidosis & improved metabolic performance.

Dose: Form: Citrate
Individual RCT; small sample size; effect may not generalize to all exercise modalities.
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Supports fluid balance during long or hot training sessions.

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Community Insights
Forms & usage
How to take it

Take 500 mg/kg body weight in capsule form about 60 minutes before exercise.

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