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Selenium

Selenium is an essential trace mineral incorporated into selenoproteins including glutathione peroxidase & thioiodothyronine deiodinases; the thyroid contains the highest selenium concentration per gram of any tissue, & supplementation reduces thyroid antibodies & supports hormone synthesis in deficient individuals.

thyroidantioxidantimmunelongevityhormonal

Evidence last reviewed: 04 Apr 2026

Evidence
2 records
2 recordsBest grade:Moderate

Moderate evidence suggests selenium supplementation can significantly reduce thyroid antibodies in individuals with Hashimoto's thyroiditis. While the thyroid's high selenium concentration highlights its importance, more research is needed to fully understand its broader effects on thyroid function and immune parameters.

Thyroid function, selenium biochemistry, & immune parameters
General population and patients with thyroid disorders · review
Moderate

A comprehensive review confirmed that the thyroid gland contains the highest selenium concentration per gram of any organ; selenium is indispensable for the synthesis of thyroid hormones (as deiodinase cofactor), & deficiency impairs T4-to-T3 conversion; supplementation in autoimmune thyroiditis reduces antibody titers & may improve quality of life.

Dose: 0 mgDuration: ongoing
Thyroid antibodies (TPOAb) & thyroid function in Hashimoto thyroiditis
Adults with Hashimoto autoimmune thyroiditis · systematic review and meta-analysis of RCTs
Moderate

Meta-analysis of 35 RCTs (n=2,358) found selenium supplementation significantly decreased TPOAb levels in patients not on thyroid hormone replacement, lowered TSH, & reduced malondialdehyde; adverse effects were comparable to placebo (moderate certainty of evidence).

Dose: 0 mgDuration: 3–12 months
Dose expressed in mg (200 mcg = 0.2 mg). Organic selenium forms (selenomethionine) preferred over inorganic forms.
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Ashwagandha
600mg
L-Carnitine / Acetyl-L-Carnitine (ALCAR)
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Iodine
150mg
Selenium
100mg
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Vitamin D3
1000mg
Electrolytes (Sodium / Potassium / Magnesium blend)
1000mg
Fish Oil
2000mg
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Community Insights
Forms & usage
How to take it

Take 100-200 mcg daily with food for optimal absorption.

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