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Resveratrol

Polyphenol found in red grapes; SIRT1 activator. Mixed clinical results despite strong preclinical data.

longevitymetabolicantioxidant

Evidence last reviewed: 04 Apr 2026

Evidence
1 record
1 recordBest grade:Low
Biomarkers
Blood PressureBlood Glucose

The evidence for resveratrol's benefits on metabolic health and cardiovascular markers is mixed, with some studies showing positive effects while others report no significant changes. The variability in results highlights the need for more consistent research and better formulations to improve bioavailability.

Metabolic health / cardiovascular markers
Adults with metabolic risk factors · RCTs (mixed results)
Low

Inconsistent across trials; some studies show blood pressure & glucose improvements; others null.

Dose: 500 mgDuration: 4–12 weeks
Bioavailability is a key limitation; may interact with anticoagulants.
Stacks containing Resveratrol
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cardiovascularlongevityantioxidant

Lycopene & resveratrol are combined to support cardiovascular health & longevity. Lycopene provides antioxidant support & promotes heart health, while resveratrol offers anti-aging benefits.

Lycopene
10mg
Resveratrol
100mg
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Forms & usage
How to take it

Take 100-500 mg daily with meals; consider enhanced formulations for better absorption.

Trans-resveratrol
Active isomer; bioavailability is inherently low.
Micronised resveratrol
Improved absorption formulations available.
Safety & trade-offs3
Interaction

Inhibits CYP3A4 — clinically significant interactions with statins, blood thinners, and immunosuppressants

Tolerance

Very low oral bioavailability without formulation support (phospholipid complex, micronisation) — plain powder largely wasted

Hormones

Possible weak estrogenic activity at high doses

High  Moderate   Low / note

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