High-dose omega-3 supplementation shows strong evidence for reducing triglycerides in adults with elevated levels. While there are some benefits for muscle soreness and cardiovascular outcomes, the evidence is less robust and varies based on dosage and individual health status.
Triglyceride reductionAdults with hypertriglyceridemia · Systematic review and meta-analysis of RCTsHigh
High-dose omega-3 (≥2 g EPA+DHA/day) consistently reduces fasting triglycerides by 15–30% in adults with elevated baseline levels.
Delayed-onset muscle soreness (DOMS) after eccentric exerciseHealthy adults performing eccentric exercise · Systematic review and meta-analysis of RCTsLow
Omega-3 PUFA supplementation produced a statistically significant reduction in DOMS (MD −0.93, 95% CI −1.44 to −0.42; p=0.0004) across 12 RCTs, though the effect size fell below the minimal clinically important difference of 1.4 on a 10-point VAS. Low-quality evidence overall.
Cardiovascular outcomes & mortalityGeneral adults and cardiovascular risk populations · Systematic review and meta-analysisModerate
Omega-3 supplementation associated with reductions in cardiovascular events; benefit most consistent at higher EPA+DHA doses (≥2 g/day) & in high-risk populations.
Longevity & Heart Health Base
Targets cardiometabolic markers associated with long-term health.
Longevity & Metabolic Health Base
Foundational stack aimed at mitochondrial function, insulin sensitivity, & long-term healthspan.
Your personalized stack
Built from your goals & the supplement evidence library. You can edit doses & timing.
Forms & usage▾
Take 1–2 grams of EPA+DHA daily with food for best absorption.
Safety & trade-offs2▾
Fishy aftertaste/burps — take with food or use enteric-coated softgels
Mild anticoagulant effect — caution pre-surgery or with blood thinners
Context: doses >3g EPA+DHA/day
●High ●Moderate ● Low / note