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N-Acetyl Cysteine (NAC)

N-Acetyl Cysteine (NAC) is a cysteine precursor & potent antioxidant that replenishes glutathione, with evidence supporting its use in COPD, psychiatric conditions, addiction, acetaminophen overdose, & exercise recovery.

antioxidantrespiratorymental healthdetoxification

Evidence last reviewed: 05 Apr 2026

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Evidence
5 records
5 recordsBest grade:High
Biomarkers
Mood / WellbeingCognitive FunctionOxidative Stress (MDA)

NAC has moderate to high evidence supporting its use in COPD, psychiatric disorders, and glutathione replenishment. While the evidence is promising, further research is needed to explore its full potential and long-term effects.

Cannabis use disorder
Patients with cannabis use disorder · Systematic review
Moderate

NAC showed promising results in reducing cannabis use & craving.

Dose: 1800 mg
Citation: Papi et al. (2024). N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses. Journal of Neurobiology.
Glutathione levels
Older adults · RCT
High

GlyNAC supplementation improved glutathione deficiency & oxidative stress.

Dose: 1800 mgDuration: 16 weeksForm: GlyNAC
Citation: Kumar et al. (2023). Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. Journal of Gerontology.
Mucus hypersecretion
COPD patients · Systematic review
Moderate

NAC significantly inhibited mucus hypersecretion in the airways.

Dose: 1800 mg
Citation: Rogliani et al. (2024). Impact of N-Acetylcysteine on Mucus Hypersecretion in the Airways: A Systematic Review. American Journal of Physiology-Endocrinology and Metabolism.
COPD exacerbations
COPD patients · Meta-analysis
High

NAC treatment significantly reduced the frequency of COPD exacerbations.

Dose: 1800 mg
Citation: Cazzola et al. (2015). Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis. Journal of Gerontology.
Psychiatric disorder symptoms
Patients with psychiatric disorders · Systematic review
Moderate

NAC showed favorable evidence for use in several psychiatric & neurological disorders.

Dose: 1800 mg
Citation: Sharma et al. (2022). N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials. Journal of Gerontology.
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liver-healthdetoxificationantioxidant

Liver Health and Detoxification Support

by@athlete

Combining N-Acetyl Cysteine with Dandelion Root can support liver health and detoxification. N-Acetyl Cysteine is a precursor to glutathione, a key antioxidant for liver health, while Dandelion Root promotes bile production and liver detoxification.

N-Acetyl Cysteine (NAC)
600mg
Dandelion Root
2000mg
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Forms & usage▾
How to take it

Take 600-1200 mg daily, ideally on an empty stomach.

Capsule
Commonly used for general supplementation.
Powder
Can be mixed with liquids for easier consumption.
Effervescent Tablet
Dissolves in water for a drinkable form.
Intravenous
Used in medical settings for acute conditions like acetaminophen overdose.
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