The evidence for myo-inositol shows moderate support for improving insulin sensitivity and hormonal profiles in women with PCOS, but the data on its effects on mood disorders is very low and inconclusive. More robust studies are needed to clarify its benefits in these areas.
Insulin sensitivity / hormonal markers in PCOSWomen with PCOS · Meta-analyses of RCTsHigh
Reliably improves insulin resistance, androgen levels, & menstrual regularity in PCOS; comparable to metformin in some studies.
Insulin resistance & hormonal markers in PCOSWomen with polycystic ovary syndrome (PCOS) · Systematic review and meta-analysis of RCTsModerate
Myo-inositol supplementation improved insulin sensitivity, reduced fasting insulin, & improved androgen profiles vs placebo in women with PCOS; fewer gastrointestinal adverse events than metformin.
Depression & anxiety symptomsAdults with depressive or anxiety disorders (7 depression RCTs, n=242; 4 anxiety RCTs, n=70) · Systematic review and meta-analysis of RCTsVery low
No statistically significant overall effect of inositol on depressive, anxiety, or OCD symptoms vs placebo; a non-significant trend toward benefit in PMDD subgroup (p=0.07). Evidence base is small & heterogeneous.
Ovulation, fertility, & reproductive outcomes in PCOSWomen with PCOS seeking fertility or ART · Systematic review and meta-analysis (30 trials, n=2230) informing 2023 international PCOS guidelinesLow
Inositol (myo-inositol or D-chiro-inositol) shows evidence of benefit for some metabolic measures & potential benefit for ovulation induction in PCOS; evidence for IVF-related outcomes (oocyte quality, fertilization, clinical pregnancy) is promising but rated as limited & inconclusive by guideline authors.
This stack addresses the key nutritional & hormonal drivers of female fertility. Folate is essential for DNA synthesis & embryo development. Myo-inositol is the most evidence-backed intervention for improving ovarian function, egg quality, & cycle regularity — particularly in PCOS. CoQ10 restores mitochondrial energy in aging oocytes, & Vitex supports luteal phase adequacy through LH modulation.
My Sample Stack
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
Forms & usage▾
Typically taken in doses of 2-4 grams daily, preferably with food.