Modafinil
Modafinil is a wakefulness-promoting agent approved for narcolepsy & shift work disorder, & is widely used off-label as a cognitive enhancer with evidence for improving attention, working memory, & decision-making.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Modafinil has strong evidence for promoting wakefulness in narcolepsy and moderate evidence for cognitive enhancement in specific populations. However, its off-label use as a cognitive enhancer requires caution and further research.
WakefulnessAdults with narcolepsy · Systematic reviewHigh
Modafinil is effective in promoting wakefulness in patients with narcolepsy.
Cognitive enhancementAdults with treatment-resistant depression · Systematic reviewModerate
Modafinil showed significant efficacy in cognitive enhancement compared to placebo.
Treatment of stimulant use disorderAdults with amphetamine-type stimulant use disorder · Systematic review and meta-analysisModerate
Modafinil showed efficacy in the treatment of amphetamine-type stimulant use disorder.
Cognitive & Energy Enhancement
Modafinil & methylene blue are combined to enhance cognitive function & energy levels. Modafinil is a wakefulness-promoting agent that improves focus, while methylene blue supports mitochondrial function & cognitive performance.