Strong evidence supports folic acid's role in preventing neural tube defects, particularly in women planning pregnancy. The MRC Vitamin Study demonstrated a significant protective effect in women with previous NTD-affected pregnancies. While the evidence is robust, individual health factors should still be considered.
Neural tube defect prevention — landmark RCTWomen with prior NTD-affected pregnancy · Randomized controlled trialHigh
The MRC Vitamin Study found a 72% protective effect of folic acid (4 mg/day) against recurrence of neural tube defects in a landmark double-blind multinational RCT of 1,195 completed pregnancies.
Neural tube defect preventionWomen capable of becoming pregnant · Guideline / public health recommendationHigh
Daily 400 mcg folic acid is recommended preconception to reduce neural tube defect risk.
This stack addresses the key nutritional & hormonal drivers of female fertility. Folate is essential for DNA synthesis & embryo development. Myo-inositol is the most evidence-backed intervention for improving ovarian function, egg quality, & cycle regularity — particularly in PCOS. CoQ10 restores mitochondrial energy in aging oocytes, & Vitex supports luteal phase adequacy through LH modulation.
Forms & usage▾
Take 400 mcg of folic acid daily, ideally starting before conception.