DMAE (Dimethylaminoethanol)

DMAE is a choline precursor found in fish that supports acetylcholine synthesis, often marketed for cognitive enhancement and mood stabilization. Preliminary evidence suggests benefits for attention, mood, and skin firming when used topically.

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Evidence last reviewed: 20 Apr 2026

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Evidence

3 records

3 recordsBest grade:Moderate

Biomarkers

Cognitive Function

Moderate evidence indicates that DMAE may improve cognitive function and skin firmness. While results are promising, more extensive research is needed to confirm these benefits and understand long-term effects.

skin firming

general population with aging skin · RCT

Moderate

3% DMAE facial gel applied daily improved skin firmness.

Dose: 350 mgDuration: 16 weeksForm: Topical GelTiming: daily

Citation: Grossman et al. (2005). The role of dimethylaminoethanol in cosmetic dermatology. Journal.

cognitive function

subjects with threshold emotional disturbance · RCT

Moderate

DMAE-containing supplement reduced theta and alpha1 power in EEG, indicating potential cognitive benefits.

Dose: 350 mgDuration: 12 weeksForm: CapsuleTiming: daily

Citation: Dimpfel et al. (2003). Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. Journal.

skin tensile effect

general population · RCT

Moderate

DMAE gel showed a significant cutaneous tensile effect compared to placebo.

Dose: 350 mgForm: Topical Gel

Citation: Uhoda et al. (2002). Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Journal.

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Enhanced Cognitive Performance

by@athlete

Combining DMAE with Uridine Monophosphate can enhance cognitive function and focus. DMAE is known for its role in improving attention and mental clarity, while Uridine supports neuroplasticity and cognitive enhancement.

DMAE (Dimethylaminoethanol)

350mg

Uridine Monophosphate

500mg

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Forms & usage▾

How to take it

Take 100-300 mg daily, preferably with meals.

Capsule

Common oral form for cognitive and mood support.

Topical Gel

Used for skin firming and cosmetic purposes.

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