Buspirone
Buspirone is a non-benzodiazepine anxiolytic that acts on 5-HT1A receptors, used primarily for generalized anxiety disorder without the dependence, sedation, or cognitive impairment associated with benzodiazepines.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Buspirone has moderate evidence supporting its efficacy and tolerability for generalized anxiety disorder. However, the findings are limited by the scope of the studies and the need for further research.
Generalized anxiety disorderAdult outpatients with generalized anxiety disorder · Systematic reviewModerate
Buspirone was included as an effective treatment choice for generalized anxiety disorder across classes of medication.
Generalized anxiety disorderAdult outpatients with generalized anxiety disorder · Systematic review and network meta-analysisModerate
Buspirone was found to be efficacious & well tolerated for generalized anxiety disorder, though findings were limited by small sample sizes.
Generalized anxiety disorderAdult outpatients with generalized anxiety disorder · Systematic reviewModerate
Buspirone was found to be efficacious & well tolerated for generalized anxiety disorder, though findings were limited by small sample sizes.
Stress Reduction & Mood Enhancement
Kava & buspirone are combined to reduce stress & enhance mood. Kava provides calming effects, while buspirone is an anxiolytic that helps manage anxiety & improve mood.