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Bromelain

Bromelain is a pineapple-derived enzyme known for its anti-inflammatory & fibrinolytic properties, often used for osteoarthritis, sinusitis, wound healing, & sports injury recovery.

anti inflammatoryrecoveryjoint healthimmune

Evidence last reviewed: 05 Apr 2026

Evidence
4 records
4 recordsBest grade:Moderate
Biomarkers
IL-6TNF-αCRP (Inflammation)

Moderate evidence supports bromelain's effectiveness in reducing pain and inflammation, particularly after surgery and in inflammatory conditions. However, the evidence for tendon healing is limited and requires further research.

Inflammation reduction
Adults with inflammatory conditions · Systematic review
Moderate

Bromelain reduced IL-1β, IL-6, & TNF-α secretion in immune cells.

Dose: 500 mg
Postoperative healing
Patients undergoing breast conservative surgery · RCT
Moderate

Bromelain reduced pain, edema, & inflammation, aiding postoperative healing.

Dose: 500 mg
Tendon healing
Adults with tendinopathy · Systematic review
Low

Bromelain showed potential in reducing inflammation & improving tendon healing.

Dose: 500 mg
Pain & swelling reduction
Patients post third molar surgery · RCT
Moderate

Bromelain reduced pain, swelling, & trismus compared to placebo.

Dose: 500 mgDuration: 7 daysForm: Lyophilized pineapple extractTiming: Initiated on the day of surgery
Stacks containing Bromelain
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jointinflammationrecovery

Boswellia & bromelain are combined to support joint health & reduce inflammation. Boswellia has anti-inflammatory properties, while bromelain aids in reducing swelling & improving joint function.

Boswellia Serrata
300mg
Bromelain
500mg
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Forms & usage
How to take it

Take 500-1000 mg of bromelain on an empty stomach, ideally before meals.

Capsule
Commonly used for standardized dosing.
Tablet
Available in various dosages for oral consumption.
Powder
Can be mixed with liquids for easier ingestion.
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