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Stress Reduction and Mood Balance

Combining Holy Basil with L-Theanine can reduce stress and balance mood. Holy Basil is an adaptogen that helps manage stress, while L-Theanine promotes relaxation without sedation.

What this is for
General support
stress, mood, anxiety
Why you are seeing this
Goal fit: stress, mood, anxiety.
What to do next
Add body metrics if you want dose previews to reflect your weight rather than the reference dose.
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Buy stack
Public•Built 20 Apr 2026•2 ingredients•No interactions detected
Core stack
The main ingredients doing the work.
2 key items
Holy Basil (Tulsi)Moderate
Daily with meals •
Holy Basil is an adaptogen that helps manage stress.
Buy ingredient →
300mg
immune-function
Moderate
Population: healthy volunteers
Study type: RCT
Dose context: 300 mg typical (range: 300–300 mg)

Tulsi leaves extract demonstrated immunomodulatory effects.

Citation: Devpura et al. (2021). Randomized placebo-controlled pilot clinical trial on the efficacy of ayurvedic treatment regime on COVID-19 positive patients.•DOI: 10.1016/j.phymed.2021.153494
cognitive-function
Low
Population: general population
Study type: Systematic review
Dose context: 600 mg typical

Tulsi is noted for its potential neuroprotective & cognitive-enhancing effects.

Citation: Kushwah et al. (2023). Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint.•DOI: 10.2174/1570159X21666230216094353
Discusses potential benefits in Alzheimer's disease.
immune-function
Moderate
Population: healthy volunteers
Study type: RCT
Dose context: 300 mg typical (range: 300–300 mg) • Duration: 4 weeks

Tulsi extract significantly increased levels of IFN-γ, IL-4, T-helper cells, & NK-cells.

Citation: Megalaa et al. (2018). A comparative evaluation of the anticaries efficacy of herbal extracts (Tulsi and Black myrobalans) and sodium fluoride as mouthrinses in children: A randomized controlled trial.•DOI: 10.4103/ijdr.ijdr_790_16
L-TheanineModerate
Daily with meals •
L-Theanine promotes relaxation without sedation.
Buy ingredient →
100mg
Trade-offs & context
Timing

Mild drowsiness at high doses — pair with caffeine for balanced alertness or take alone in evenings

Context: doses >400mg

Attention & cognitive performance (combined with caffeine)
Moderate
Population: Healthy adults
Study type: RCT (double-blind, crossover)
Dose context: 200 mg typical (range: 100–200 mg) • Duration: Acute

L-theanine (100 mg) + caffeine (50 mg) improved attention-switching speed & accuracy vs. placebo at 60 min; L-theanine alone showed no significant cognitive effects.

Citation: Owen GN et al. Nutr Neurosci. 2008;11(4):193–198.•DOI: 10.1179/147683008X301513•https://pubmed.ncbi.nlm.nih.gov/18681988/
Most consistent evidence is for the caffeine + theanine combination, not theanine alone.
Cognitive function (standalone L-theanine)
Low
Population: Healthy adults (5 RCTs, n=148)
Study type: Systematic review & meta-analysis of RCTs
Dose context: 200 mg typical (range: 100–400 mg) • Duration: Acute to 4 weeks

L-theanine showed dose-dependent effects on rapid visual information processing & recognition reaction time; non-significant for simple reaction time & Stroop. Overall evidence promising but not conclusive.

Citation: Dróżdż W et al. Nutrients. 2025;17(3):449.•DOI: 10.3390/nu17030449•https://pubmed.ncbi.nlm.nih.gov/41227106/
Standalone effects are less consistent than combination with caffeine.
Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
L-Theanine
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~2.5h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

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