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CaffeineHighMorning or pre-workout • Caffeine anhydrous • Caffeine acutely improves multiple performance outcomes; common effective range is ~3–6 mg/kg in many studies, with high inter-individual variability.200mg
Impairs sleep onset and deep sleep if consumed within 8–10 hours of bedtime
Tolerance develops within 1–2 weeks of daily use, reducing efficacy
Withdrawal: headache and fatigue on cessation after sustained daily use
Elevated heart rate, anxiety, jitteriness — individual sensitivity varies widely
Context: doses >400mg
Strong evidence that 3–6 mg/kg caffeine improves endurance, strength, & power; benefits consistent but moderated by genetics & habituation.
Caffeine significantly improves reaction time (g=0.28) & accuracy (g=0.27) on attention tasks; dose ≥200 mg shows larger effects.
Caffeine prolongs sleep latency, reduces total sleep time & efficiency; clinically meaningful disruption occurs with 400 mg within 8–12 h of bedtime.
Beta-AlanineModerateDaily (any time) • Beta-alanine • Chronic beta-alanine supplementation increases muscle carnosine & can improve performance, commonly using multi-gram daily dosing over weeks.3200mg
Significant overall effect size (ES = 0.18, 95% CI 0.08–0.28); greatest benefit for exercise in 1–10 min duration window.
4–6 g/day for ≥4 weeks significantly augments muscle carnosine (intracellular pH buffer) & improves exercise lasting 1–4 min; no benefit for efforts <60 s.
50mg
Vitamin D at 700–800 IU/day reduced hip fracture risk by 26% (RR 0.74) & any nonvertebral fracture by 23% (RR 0.77); no significant benefit was observed at 400 IU/day.
Vitamin D supplementation reduced risk of acute respiratory tract infection (adjusted OR 0.88, 95% CI 0.81–0.96); greatest benefit in those with baseline deficiency (<25 nmol/L) & those receiving daily or weekly dosing rather than bolus doses.
Vitamin D insufficiency is prevalent among athletes, particularly indoor athletes & those in northern latitudes in winter. Insufficiency is associated with reduced muscle strength, power, & endurance; supplementation of 2,000–6,000 IU/day recommended to maintain 25(OH)D >40 ng/mL.
Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.
Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.
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My Sample Stack
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
Your personalized stack
Built from your goals & the supplement evidence library. You can edit doses & timing.
Gut-Friendly Daily Base
Supports digestive resilience & long-term gut health.