Supplementation with urolithin A may improve immune function as we age, in addit
The claims about urolithin A improving muscle strength and endurance are somewhat supported by evidence, but the claims regarding immune aging and specific immune cell effects are not directly supported by the provided evidence. The evidence supports improvements in muscle endurance and mitochondrial health at doses up to 1000 mg, but does not confirm the immune-related benefits claimed.
“Urolithin A may slow immune aging and improve immune function by increasing CD8-positive T cells and shifting energy metabolism.”
The provided evidence does not address immune aging or specific immune cell effects, focusing instead on muscle endurance and mitochondrial health.
“Urolithin A improves muscle strength, endurance, and VO2 max.”
Evidence supports improvements in muscle endurance and mitochondrial health, but does not specifically confirm VO2 max improvements or quantify strength gains at the claimed level.
“Urolithin A is a potent inducer of mitophagy, improving mitochondrial health.”
The evidence indicates that urolithin A improves mitophagy markers and mitochondrial health.
Supplementation with urolithin A may improve immune function as we age, in addition to improving muscle strength, exercise performance, and biomarkers of mitochondrial health, including mitophagy. Urolithin A has produced ~10–12% improvements in lower-body strength, as well as gains in VO2 max and local muscle endurance, alongside favorable mitochondrial and inflammatory biomarkers. There’s even a recovery-oriented signal in trained athletes. In a new month-long study, urolithin A supplementation (1000 mg/day) promoted a more “youthful” immune system environment characterized by a robust immune response and a lower inflammatory burden, alongside improved mitochondrial efficiency. This suggests that this gut-derived metabolite (some people produce it after eating pomegranates and walnuts, but others need to supplement directly) supports mitochondrial health and immune function, with performance benefits most evident in strength/endurance capacity. Study title: “Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial” #mitochondria #pomegranates #immunity