StackTerminal.Health

BETA
@foundmyfitness

Supplementation with urolithin A may improve immune function as we age, in addit

MIXED
TrustworthinessMixed

The claims about urolithin A improving muscle strength and endurance are somewhat supported by evidence, but the claims regarding immune aging and specific immune cell effects are not directly supported by the provided evidence. The evidence supports improvements in muscle endurance and mitochondrial health at doses up to 1000 mg, but does not confirm the immune-related benefits claimed.

Creator history
See @foundmyfitness's full track record — how often their claims check out.
PRO
Detected Supplements (1)
Urolithin A
Moderate
1000mg mentionedDose in range
Urolithin AUnsupported

Urolithin A may slow immune aging and improve immune function by increasing CD8-positive T cells and shifting energy metabolism.

The provided evidence does not address immune aging or specific immune cell effects, focusing instead on muscle endurance and mitochondrial health.

Urolithin AOverstated

Urolithin A improves muscle strength, endurance, and VO2 max.

Evidence supports improvements in muscle endurance and mitochondrial health, but does not specifically confirm VO2 max improvements or quantify strength gains at the claimed level.

Urolithin ASupported

Urolithin A is a potent inducer of mitophagy, improving mitochondrial health.

The evidence indicates that urolithin A improves mitophagy markers and mitochondrial health.

Transcript
Auto-generated from the reel audio.
Supplementing with urolithin-A may slow immune aging in addition to improving muscular performance, endurance, and markers of mitochondrial health such as mitophagy. Previous studies have found that supplementing with 500 milligrams of urolithin-A can improve muscle strength in older adults. If people up that dose to about a thousand milligrams a day, that also seems to improve endurance performance and VO2 max as well. And this new study suggests that supplementing with a thousand milligrams of urolithin-A for about a month seems to improve immune aging. So as we age, something called immunosenescence occurs. This is where we start to lose immune cells that are important for fighting off pathogens. Well, in this new study, it found that supplementing with urolithin-A seemed to increase the number of CD8-positive T cells. These are the cells that are important for fighting off infections from bacteria, from viruses. And it also seemed to shift the energy metabolism of these immune cells in a favorable way, where they're not relying so much on glucose, but they're also relying on other sources of fuel such as fatty acids as well. Urolithin-A is what's called a postbiotic. So it's a gut-derived metabolite that's generated from a certain polyphenol called elagitannins that are found mostly in pomegranate but also walnuts. Urolithin-A has been shown in multiple other studies to be a potent inducer of a process called mitophagy, which is essentially making mitochondria healthy by causing damaged parts of mitochondria to kind of rejuvenate themselves. So mitochondrial health is improved. Therefore, you can improve muscle endurance, you can improve muscle strength, and now what we're seeing is immune aging as well. There have been some animal studies showing that urolithin-A can also increase life expectancy. So there's a lot of new excitement with respect to this urolithin-A compound. I mentioned that you do make it from polyphenols like the elagitannins. The only problem is that it requires a certain type of gut bacteria to do that. Not everyone has those types of gut bacteria, so some people ultimately have to supplement. There's about a 50% chance that people do not have the type of bacteria that converts the elagitannins into urolithin-A and therefore supplementation becomes key. Also, we find that the dose seems to be important with higher doses of urolithin-A in the 1,000 milligrams range affecting both immune aging and endurance function as well. So something to keep an eye on. I'm definitely excited about this.
Caption

Supplementation with urolithin A may improve immune function as we age, in addition to improving muscle strength, exercise performance, and biomarkers of mitochondrial health, including mitophagy. Urolithin A has produced ~10–12% improvements in lower-body strength, as well as gains in VO2 max and local muscle endurance, alongside favorable mitochondrial and inflammatory biomarkers. There’s even a recovery-oriented signal in trained athletes. In a new month-long study, urolithin A supplementation (1000 mg/day) promoted a more “youthful” immune system environment characterized by a robust immune response and a lower inflammatory burden, alongside improved mitochondrial efficiency. This suggests that this gut-derived metabolite (some people produce it after eating pomegranates and walnuts, but others need to supplement directly) supports mitochondrial health and immune function, with performance benefits most evident in strength/endurance capacity. Study title: “Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial” #mitochondria #pomegranates #immunity