Urolithin A
Gut-derived metabolite from ellagic acid; activates mitophagy. Promising longevity & muscle endurance data.
Evidence last reviewed: 04 Apr 2026
Urolithin A is a gut-derived metabolite that may enhance muscle endurance and promote mitochondrial health. However, long-term safety data in humans is limited.
Limited long-term human safety data — trials up to 4 months only
Summarized study outcomes with population, design, grade, and effect data.
Research shows moderate evidence for Urolithin A's benefits in muscle endurance and mitochondrial function, particularly in older adults. However, the studies are short-term, and more extensive research is needed to confirm long-term safety and efficacy.
Muscle endurance / mitochondrial healthOlder adults; healthy middle-aged adults · RCTs (phase I/II)Moderate
Improved handgrip & leg muscle endurance; mitophagy markers improved; good safety profile.
Stacks containing Urolithin A
Public community stacks that include this ingredient.
Endurance, Longevity & Recovery Stack
Built from your profile goals, constraints, & current training/recovery context. This stack includes evidence-backed supplements selected for practical fit, & you can fine-tune doses & timing in edit mode.