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BETA

Vitamin C (Ascorbic Acid)

Vitamin C is a water-soluble vitamin that acts as a potent antioxidant, protecting cells from oxidative stress. It is primarily used to boost immune function, enhance collagen synthesis, and improve iron absorption. Key caveats include its water solubility, which limits storage in the body, necessitating regular intake.

immune-supportantioxidantcollagen-synthesisskin-healthiron-absorptionwound-healingcardiovascular-healthoxidative-stress
Evidence last reviewed: 29 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Note

Gastrointestinal Tolerance

Context: High doses of Vitamin C can cause gastrointestinal discomfort, including diarrhea.

Note

Kidney Stones

Context: Excessive intake of Vitamin C may increase the risk of kidney stones in susceptible individuals.

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood Pressure
Inflammation
Oxidative Stress (MDA)
Immune
Immune Function
Evidence
6 records
Immune function / cold duration
Adults with common coldRandomized Controlled Trial
COCHRANEModerate

Vitamin C supplementation was associated with a reduction in the duration of cold symptoms by approximately 8% in adults.

Dose: 1000 mgDuration: 14 daysForm: Ascorbic AcidTiming: At onset of symptoms
Collagen synthesis / skin aging
Middle-aged womenRandomized Controlled Trial
PUBMEDHigh

Supplementation with Vitamin C improved skin elasticity and reduced wrinkles, likely due to enhanced collagen synthesis.

Dose: 500 mgDuration: 12 weeksForm: Ascorbic AcidTiming: Daily
Iron absorption enhancement
Iron-deficient individualsRandomized Controlled Trial
PUBMEDHigh

Vitamin C significantly increased iron absorption from plant-based sources, improving iron status in deficient individuals.

Dose: 200 mgDuration: 8 weeksForm: Ascorbic AcidTiming: With meals
Antioxidant / oxidative stress
Adults under oxidative stressRandomized Controlled Trial
PUBMEDModerate

Vitamin C supplementation reduced markers of oxidative stress, such as malondialdehyde, in adults exposed to oxidative stress.

Dose: 500 mgDuration: 6 weeksForm: Ascorbic AcidTiming: Daily
Cardiovascular outcomes
Adults with hypertensionMeta-analysis of RCTs
PUBMEDLow

Vitamin C supplementation resulted in a modest reduction in systolic blood pressure by approximately 3.7 mmHg.

Dose: 1000 mgDuration: 8 weeksForm: Ascorbic AcidTiming: Daily
Cancer adjuvant (high-dose IV)
Patients undergoing stem cell transplantationRandomized Controlled Trial
PUBMEDLow

High-dose intravenous Vitamin C improved plasma levels and showed trends toward reduced complications in stem cell transplant patients.

Dose: 50000 mgDuration: 100 daysForm: IntravenousTiming: Daily
Forms

Stacks containing Vitamin C (Ascorbic Acid)

Public community stacks that include this ingredient.

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womens-healthconstraints

My Sample Stack

by@tin_man140_6

Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.

Vitamin B-Complex
26mg
Vitamin C
500mg
Ashwagandha
600mg
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longevityanti-agingcellular-health

Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.

Creatine Monohydrate
2500mg
Calcium Alpha-Ketoglutarate (CaAKG)
2000mg
Taurine
1500mg
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immuneantioxidantlongevity

Combining Sea Buckthorn with Vitamin C can enhance immune function and provide antioxidant defense. Sea Buckthorn is known for its immune-boosting and antioxidant properties, while Vitamin C supports immune health and reduces oxidative stress.

Sea Buckthorn
2000mg
Vitamin C
500mg
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womens-health

Minimalist approach that focuses on likely gaps & avoids mega-dosing trends.

Biotin (Vitamin B7)
2mg
Vitamin C
500mg
Zinc
15mg
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