StackTerminal.Health

BETA

Sodium Citrate

Alkalizing electrolyte salt used as a pre-exercise buffer to attenuate exercise-induced acidosis during high-intensity efforts.

electrolytes
Evidence last reviewed: 04 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Performance
Time to Exhaustion
Evidence
2 records
Blood alkalosis induction & exercise performance during high-intensity exercise
Trained athletes performing high-intensity and supramaximal exerciseNarrative review of RCTs and physiological studies
PUBMEDLow

Sodium citrate at 500 mg/kg body mass in capsule form reliably induces blood alkalosis & is most beneficial for short-duration, very high-intensity exercise; only 25% of observations showed significant performance improvements in high-intensity intermittent exercise, & gastrointestinal symptoms are a key limiting factor.

Dose: Form: Citrate
Capsule administration preferred over liquid to reduce GI distress.
Performance during supramaximal cycling (time to exhaustion)
Trained male cyclistsRandomized crossover trial
PUBMEDLow

Sodium citrate ingestion significantly increased time to exhaustion during supramaximal cycling exercise versus placebo, associated with reduced intramuscular acidosis & improved metabolic performance.

Dose: Form: Citrate
Individual RCT; small sample size; effect may not generalize to all exercise modalities.

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