StackTerminal.Health

BETA

Shiitake Mushroom

Shiitake mushrooms contain bioactive compounds like lentinan & eritadenine that support immune function, cardiovascular health, & gut microbiota.

immunecardiovasculargut-healthanti-inflammatory
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Immune
Immune Function
Evidence
4 records
immune function
cancer patientsSystematic review
PUBMEDModerate

Lentinan, a polysaccharide from Shiitake mushrooms, has been shown to activate immunocytes through multiple signaling pathways.

Dose: 1500 mgForm: Lentinan
immune function
rodent model of pulmonary sepsisRCT
PUBMEDLow

Purified β-glucans from Shiitake mushrooms reduced infection by a multidrug-resistant strain of Klebsiella pneumoniae, likely through immunomodulation.

Dose: 1500 mgForm: LentinanTiming: 1 hour post-infection
immune function
HIV-positive patientsRCT
PUBMEDModerate

Lentinan demonstrated immune modulating properties in HIV-positive patients.

Dose: 1500 mgDuration: 8-12 weeksForm: LentinanTiming: once or twice a week
oral health
young volunteersRCT
PUBMEDLow

A low molecular mass fraction of Shiitake mushroom extract showed antimicrobial & antiplaque activities in an oral rinse.

Dose: 1500 mgDuration: 11 daysForm: Low molecular mass extract
Forms
Whole Mushroom
Commonly used in culinary applications.
Extract
Concentrated form often used in supplements.
Powder
Dried and ground form for easy incorporation into foods and beverages.

Stacks containing Shiitake Mushroom

Public community stacks that include this ingredient.

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gut-healthanti-inflammatoryimmune

Combining Shiitake Mushroom with Lactoferrin can support gut health and reduce inflammation. Shiitake Mushroom is known for its immune-boosting and anti-inflammatory properties, while Lactoferrin provides antimicrobial and gut health support.

Shiitake Mushroom
1500mg
Lactoferrin
200mg
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