Resveratrol
Polyphenol found in red grapes; SIRT1 activator. Mixed clinical results despite strong preclinical data.
Evidence last reviewed: 04 Apr 2026
Resveratrol is a polyphenol with mixed clinical results, primarily known for its potential cardiovascular benefits. While it shows promise, its low bioavailability and interaction risks limit its effectiveness for many users.
Inhibits CYP3A4 — clinically significant interactions with statins, blood thinners, and immunosuppressants
Very low oral bioavailability without formulation support (phospholipid complex, micronisation) — plain powder largely wasted
Possible weak estrogenic activity at high doses
Summarized study outcomes with population, design, grade, and effect data.
The evidence for resveratrol's benefits on metabolic health and cardiovascular markers is mixed, with some studies showing positive effects while others report no significant changes. The variability in results highlights the need for more consistent research and better formulations to improve bioavailability.
Metabolic health / cardiovascular markersAdults with metabolic risk factors · RCTs (mixed results)Low
Inconsistent across trials; some studies show blood pressure & glucose improvements; others null.
Stacks containing Resveratrol
Public community stacks that include this ingredient.
Cardiovascular Health & Longevity
Lycopene & resveratrol are combined to support cardiovascular health & longevity. Lycopene provides antioxidant support & promotes heart health, while resveratrol offers anti-aging benefits.