Resveratrol
Polyphenol found in red grapes; SIRT1 activator. Mixed clinical results despite strong preclinical data.
longevitymetabolicantioxidant
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Interaction
Inhibits CYP3A4 — clinically significant interactions with statins, blood thinners, and immunosuppressants
Tolerance
Very low oral bioavailability without formulation support (phospholipid complex, micronisation) — plain powder largely wasted
Hormones
Possible weak estrogenic activity at high doses
Dot colour: ●High concern ●Moderate ● Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood Pressure
Metabolic
Blood Glucose
Evidence
1 record
Metabolic health / cardiovascular markers
Adults with metabolic risk factors • RCTs (mixed results)
PUBMEDLow
Inconsistent across trials; some studies show blood pressure & glucose improvements; others null.
Dose: 500 mgDuration: 4–12 weeks
Bioavailability is a key limitation; may interact with anticoagulants.
Forms
Trans-resveratrol
Active isomer; bioavailability is inherently low.
Micronised resveratrol
Improved absorption formulations available.
Stacks containing Resveratrol
Public community stacks that include this ingredient.
cardiovascularlongevityantioxidant
Cardiovascular Health & Longevity
by@athlete
Lycopene & resveratrol are combined to support cardiovascular health & longevity. Lycopene provides antioxidant support & promotes heart health, while resveratrol offers anti-aging benefits.
Lycopene
10mg
Resveratrol
100mg
New