Pyrroloquinoline Quinone (PQQ)

Pyrroloquinoline Quinone (PQQ) is a redox cofactor that supports mitochondrial biogenesis & provides antioxidant protection, with preliminary evidence suggesting benefits for cognitive function & energy metabolism.

energycognitiveantioxidantmitochondrial

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Cognitive FunctionMemory

Performance

Aerobic Capacity

Inflammation

Oxidative Stress (MDA)

Evidence

4 records

oxidative stress markers

elderly individuals • Pilot Study

PUBMEDLow

PQQ supplementation showed potential in reducing oxidative stress markers in elderly individuals.

Dose: 20 mgDuration: 12 weeksForm: Disodium Salt

Citation: Bosco et al. (2024). Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study. Archives of Neurology.

cognitive function

healthy volunteers • RCT

PUBMEDModerate

PQQ supplementation improved cognitive performance, including memory & attention, in healthy elderly individuals.

Dose: 21 mgDuration: 12 weeksForm: Disodium Salt

Citation: Baltic et al. (2024). The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial. Journal of Nutrition, Health & Aging.

cognitive function

middle-aged to elderly individuals • RCT

PUBMEDModerate

PQQ supplementation was found to improve memory, attention, & cognitive function in individuals experiencing age-related cognitive decline.

Dose: 20 mgDuration: 12 weeksForm: Disodium Salt

Citation: Itoh et al. (2016). Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions. JAMA Neurology.

aerobic exercise performance

untrained men • RCT

PUBMEDLow

PQQ supplementation may enhance aerobic exercise performance & mitochondrial biogenesis in untrained individuals.

Dose: 20 mgDuration: 6 weeksForm: Disodium Salt

Citation: Hwang et al. (2020). Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men. Journal of the American College of Nutrition.

Forms

Disodium Salt

Commonly used in supplements for enhanced stability and absorption.

Stacks containing Pyrroloquinoline Quinone (PQQ)

Public community stacks that include this ingredient.

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Cognitive & Neuroprotection Support

by@athlete

Pyrroloquinoline quinone (PQQ) & methylene blue are combined to support cognitive function & provide neuroprotection. PQQ supports mitochondrial function & cognitive performance, while methylene blue enhances mitochondrial function & provides neuroprotective benefits.

Pyrroloquinoline Quinone (PQQ)

20mg

Methylene Blue

2mg

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