StackTerminal.Health

BETA

Omega-3 (EPA/DHA)

Cardiometabolic & inflammation-related outcomes; can support endurance recovery signals; evidence depends on dose & baseline intake.

recoverycardiolongevity
Evidence last reviewed: 04 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Tolerance

Fishy aftertaste/burps — take with food or use enteric-coated softgels

Interaction

Mild anticoagulant effect — caution pre-surgery or with blood thinners

Context: doses >3g EPA+DHA/day

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Triglycerides
Recovery
DOMS / Muscle Soreness
Evidence
3 records
Triglyceride reduction
Adults with hypertriglyceridemiaSystematic review and meta-analysis of RCTs
PUBMEDHigh

High-dose omega-3 (≥2 g EPA+DHA/day) consistently reduces fasting triglycerides by 15–30% in adults with elevated baseline levels.

Dose: 2000–4000 mg
Delayed-onset muscle soreness (DOMS) after eccentric exercise
Healthy adults performing eccentric exerciseSystematic review and meta-analysis of RCTs
PUBMEDLow

Omega-3 PUFA supplementation produced a statistically significant reduction in DOMS (MD −0.93, 95% CI −1.44 to −0.42; p=0.0004) across 12 RCTs, though the effect size fell below the minimal clinically important difference of 1.4 on a 10-point VAS. Low-quality evidence overall.

Dose:
Statistical significance without clear clinical significance; larger doses (≥6 g/day) & longer supplementation (≥7 weeks) may be required.
Cardiovascular outcomes & mortality
General adults and cardiovascular risk populationsSystematic review and meta-analysis
PUBMEDModerate

Omega-3 supplementation associated with reductions in cardiovascular events; benefit most consistent at higher EPA+DHA doses (≥2 g/day) & in high-risk populations.

Dose:
PMC full-text review; curated cardiovascular evidence.
Forms
Triglyceride fish oil
Often used; absorption may vary.
Algal DHA/EPA
Vegetarian option.

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