Nattokinase
Enzyme from fermented soybeans with fibrinolytic activity; early evidence for cardiovascular & blood pressure benefits.
Evidence last reviewed: 04 Apr 2026
Nattokinase is an enzyme from fermented soybeans that may help with blood pressure and cardiovascular health. However, its strong blood-thinning effects require caution, especially when combined with certain medications.
Significant fibrinolytic (blood-thinning) activity — do NOT combine with warfarin, heparin, or antiplatelet drugs without medical supervision
Vitamin K2 content in natto-derived products may counteract vitamin K antagonists (warfarin)
Summarized study outcomes with population, design, grade, and effect data.
Current evidence suggests nattokinase may lead to modest reductions in blood pressure and improvements in blood viscosity markers, but the studies are small and lack large-scale trials. More research is needed to confirm these benefits and establish optimal dosing.
Blood pressure / blood viscosityAdults with hypertension or cardiovascular risk · RCTs (small)Moderate
Modest reductions in SBP/DBP; some improvements in fibrinolytic markers. Limited large-scale trial data.
Stacks containing Nattokinase
Public community stacks that include this ingredient.
Metabolic & Cardiovascular Support
NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.