Nattokinase
Enzyme from fermented soybeans with fibrinolytic activity; early evidence for cardiovascular & blood pressure benefits.
longevitycardiometabolic
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Interaction
Significant fibrinolytic (blood-thinning) activity — do NOT combine with warfarin, heparin, or antiplatelet drugs without medical supervision
Interaction
Vitamin K2 content in natto-derived products may counteract vitamin K antagonists (warfarin)
Dot colour: ●High concern ●Moderate ● Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood Pressure
Evidence
1 record
Blood pressure / blood viscosity
Adults with hypertension or cardiovascular risk • RCTs (small)
PUBMEDModerate
Modest reductions in SBP/DBP; some improvements in fibrinolytic markers. Limited large-scale trial data.
Dose: 100 mgDuration: 8–12 weeks
Citation: Kim et al. 2008; Jensen et al. 2006
Caution with anticoagulants; do not combine with blood thinners without medical supervision.
Forms
Nattokinase (2000 FU per capsule)
Dosed in fibrinolytic units (FU).
Stacks containing Nattokinase
Public community stacks that include this ingredient.
metaboliccardiovascularlongevity
Metabolic & Cardiovascular Support
by@athlete
NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.
NAD+ Precursors (NMN/NR)
250mg
Nattokinase
100mg
New