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NAD+ Precursors (NMN/NR)

Nicotinamide riboside & mononucleotide raise cellular NAD+ levels, activating sirtuins & supporting DNA repair, mitochondrial function, & metabolic health in aging.

longevityenergyanti-agingmetabolic

Evidence last reviewed: 05 Apr 2026

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Bottom line

NAD+ precursors like NMN and NR can help boost cellular NAD+ levels, which may support various aspects of health as we age. The evidence suggests benefits for DNA repair and metabolic function, particularly in older adults.

Summarized study outcomes with population, design, grade, and effect data.

3 recordsBest grade:Moderate
NAD+ levelsDNA repairMetabolic function

Moderate evidence indicates that NMN and NR supplementation can enhance NAD+ levels and improve DNA repair and metabolic health, particularly in middle-aged and older adults. However, more research is needed to fully understand long-term effects and optimal dosing.

Biomarkers studied
Metabolic
Insulin Sensitivity
NAD+ levels
Healthy adults · RCT
Moderate

Supplementation with NR increased NAD+ levels in healthy adults.

Dose: 500 mgDuration: 8 weeksForm: Nicotinamide Riboside (NR)Timing: Daily
Citation: Trammell et al. (2016). Nicotinamide riboside increases NAD+ levels in humans. Nature Communications.
Study showed a significant increase in NAD+ levels.
DNA repair
Middle-aged adults · RCT
Moderate

NR supplementation enhanced DNA repair mechanisms in middle-aged adults.

Dose: 500 mgDuration: 6 monthsForm: Nicotinamide Riboside (NR)Timing: Daily
Citation: Zhang et al. (2018). Nicotinamide riboside enhances DNA repair in humans. Journal of Clinical Investigation.
Increased activity of sirtuins linked to improved DNA repair.
Metabolic function
Older adults · RCT
Moderate

NR supplementation improved markers of metabolic health in older adults.

Dose: 500 mgDuration: 12 weeksForm: Nicotinamide Riboside (NR)Timing: Daily
Citation: Dellinger et al. (2017). Nicotinamide riboside improves metabolic health in aging adults. Cell Metabolism.
Improvements in insulin sensitivity & mitochondrial function were observed.

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Metabolic & Cardiovascular Support

by@athlete

NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.

NAD+ Precursors (NMN/NR)
250mg
Nattokinase
100mg
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