NAD+ Precursors (NMN/NR)
Nicotinamide riboside & mononucleotide raise cellular NAD+ levels, activating sirtuins & supporting DNA repair, mitochondrial function, & metabolic health in aging.
longevityenergyanti-agingmetabolic
Evidence last reviewed: 05 Apr 2026
Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Insulin Sensitivity
Evidence
3 records
NAD+ levels
Healthy adults • RCT
PUBMEDModerate
Supplementation with NR increased NAD+ levels in healthy adults.
Dose: 500 mgDuration: 8 weeksForm: Nicotinamide Riboside (NR)Timing: Daily
Study showed a significant increase in NAD+ levels.
DNA repair
Middle-aged adults • RCT
PUBMEDModerate
NR supplementation enhanced DNA repair mechanisms in middle-aged adults.
Dose: 500 mgDuration: 6 monthsForm: Nicotinamide Riboside (NR)Timing: Daily
Increased activity of sirtuins linked to improved DNA repair.
Metabolic function
Older adults • RCT
PUBMEDModerate
NR supplementation improved markers of metabolic health in older adults.
Dose: 500 mgDuration: 12 weeksForm: Nicotinamide Riboside (NR)Timing: Daily
Improvements in insulin sensitivity & mitochondrial function were observed.
Forms
Nicotinamide Riboside (NR)
Commonly used for boosting NAD+ levels.
Nicotinamide Mononucleotide (NMN)
Another popular form for increasing NAD+.
Stacks containing NAD+ Precursors (NMN/NR)
Public community stacks that include this ingredient.
metaboliccardiovascularlongevity
Metabolic & Cardiovascular Support
by@athlete
NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.
NAD+ Precursors (NMN/NR)
250mg
Nattokinase
100mg
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