Myo-Inositol

Naturally occurring sugar alcohol with roles in insulin signalling, PCOS management, and neurological function.

womens-healthmetabolic-healthhormonal-healthlongevity

Dosing model

FLATFixed dose (no body-weight scaling).

Min dose

2000 mg

Max dose

4000 mg

Rounding

500 mg

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Evidence

3 records

Insulin resistance and hormonal markers in PCOS

Women with polycystic ovary syndrome (PCOS) • Systematic review and meta-analysis of RCTs

Moderate

Myo-inositol supplementation improved insulin sensitivity, reduced fasting insulin, and improved androgen profiles vs placebo in women with PCOS; fewer gastrointestinal adverse events than metformin.

Dose: 4000 mg • Duration: 12–24 weeks

Citation: Unfer V, Facchinetti F, Orrù B, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocr Connect. 2017;6(8):647-658.

Ovulation, fertility, and reproductive outcomes in PCOS

Women with PCOS seeking fertility or ART • Systematic review and meta-analysis (30 trials, n=2230) informing 2023 international PCOS guidelines

Low

Inositol (myo-inositol or D-chiro-inositol) shows evidence of benefit for some metabolic measures and potential benefit for ovulation induction in PCOS; evidence for IVF-related outcomes (oocyte quality, fertilization, clinical pregnancy) is promising but rated as limited and inconclusive by guideline authors.

Dose: —

Citation: Fitz V, Graca S, Mahalingaiah S, et al. Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines. J Clin Endocrinol Metab. 2024;109(4):e1inositol.

Authors note uncertainty; treatment decisions should incorporate patient values and preferences.

Depression and anxiety symptoms

Adults with depressive or anxiety disorders (7 depression RCTs, n=242; 4 anxiety RCTs, n=70) • Systematic review and meta-analysis of RCTs

Very low

No statistically significant overall effect of inositol on depressive, anxiety, or OCD symptoms vs placebo; a non-significant trend toward benefit in PMDD subgroup (p=0.07). Evidence base is small and heterogeneous.

Dose: —

Citation: Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol. 2014;29(1):55-63.

Insufficient evidence to support inositol for depression/anxiety; PMDD signal warrants further study.