StackTerminal.Health

BETA

Myo-Inositol

Naturally occurring sugar alcohol with roles in insulin signalling, PCOS management, & neurological function.

womens-healthmetabolic-healthhormonal-healthlongevity
Evidence last reviewed: 04 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Hormonal
Insulin
Metabolic
Insulin Sensitivity
Cognitive
Anxiety
Evidence
3 records
Insulin resistance & hormonal markers in PCOS
Women with polycystic ovary syndrome (PCOS)Systematic review and meta-analysis of RCTs
PUBMEDModerate

Myo-inositol supplementation improved insulin sensitivity, reduced fasting insulin, & improved androgen profiles vs placebo in women with PCOS; fewer gastrointestinal adverse events than metformin.

Dose: 4000 mgDuration: 12–24 weeks
Depression & anxiety symptoms
Adults with depressive or anxiety disorders (7 depression RCTs, n=242; 4 anxiety RCTs, n=70)Systematic review and meta-analysis of RCTs
PUBMEDVery low

No statistically significant overall effect of inositol on depressive, anxiety, or OCD symptoms vs placebo; a non-significant trend toward benefit in PMDD subgroup (p=0.07). Evidence base is small & heterogeneous.

Dose:
Insufficient evidence to support inositol for depression/anxiety; PMDD signal warrants further study.
Ovulation, fertility, & reproductive outcomes in PCOS
Women with PCOS seeking fertility or ARTSystematic review and meta-analysis (30 trials, n=2230) informing 2023 international PCOS guidelines
PUBMEDLow

Inositol (myo-inositol or D-chiro-inositol) shows evidence of benefit for some metabolic measures & potential benefit for ovulation induction in PCOS; evidence for IVF-related outcomes (oocyte quality, fertilization, clinical pregnancy) is promising but rated as limited & inconclusive by guideline authors.

Dose:
Authors note uncertainty; treatment decisions should incorporate patient values & preferences.

Stacks containing Myo-Inositol

Public community stacks that include this ingredient.

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womens-healthfertilitypreconception

This stack addresses the key nutritional & hormonal drivers of female fertility. Folate is essential for DNA synthesis & embryo development. Myo-inositol is the most evidence-backed intervention for improving ovarian function, egg quality, & cycle regularity — particularly in PCOS. CoQ10 restores mitochondrial energy in aging oocytes, & Vitex supports luteal phase adequacy through LH modulation.

Folic Acid (Folate, B9)
0mg
Myo-Inositol
4000mg
Coenzyme Q10
600mg
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