Metformin

Metformin is a biguanide antidiabetic medication primarily used to control blood glucose levels in individuals with type 2 diabetes. It is also being studied for its potential benefits in longevity, cancer prevention, & metabolic syndrome.

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Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Hormonal

Insulin

Metabolic

Blood GlucoseInsulin SensitivityBMIBody Weight

Evidence

5 records

Blood glucose control

Patients with type 2 diabetes • Systematic review

PUBMEDHigh

Metformin is effective in controlling blood glucose levels in patients with type 2 diabetes.

Dose: 1500 mg

Citation: Nabrdalik et al. (2022). Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials. Molecules.

Insulin sensitivity

Women with polycystic ovary syndrome (PCOS) • Systematic review

PUBMEDModerate

Metformin is widely used to treat insulin resistance in PCOS, although it may cause gastrointestinal side effects.

Dose: 1500 mg

Citation: Greff et al. (2023). Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reproductive Biology and Endocrinology.

Weight management

Patients with obesity • Systematic review

PUBMEDModerate

Metformin has been shown to aid in weight management in patients with obesity.

Dose: 1500 mg

Citation: Masarwa et al. (2021). Efficacy and Safety of Metformin for Obesity: A Systematic Review. International Journal of Molecular Sciences.

Cancer incidence

General population • Systematic review

PUBMEDModerate

Metformin use is associated with a reduced incidence of cancer.

Dose: 1500 mg

Citation: O'Connor et al. (2024). Association of metformin use and cancer incidence: a systematic review and meta-analysis. Hormone Research in Paediatrics.

All-cause mortality

Patients with type 2 diabetes • Systematic review

PUBMEDModerate

Metformin reduces all-cause mortality & diseases of aging independent of its effect on diabetes control.

Dose: 1500 mg

Citation: Campbell et al. (2017). Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Journal of Endocrinological Investigation.

Forms

Tablet

Most common form, taken orally.

Extended-release tablet

Designed to reduce gastrointestinal side effects.

Stacks containing Metformin

Public community stacks that include this ingredient.

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Metabolic Health & Weight Management

by@athlete

Metformin & intermittent fasting are combined to support metabolic health & weight management. Metformin improves insulin sensitivity & glucose metabolism, while intermittent fasting aids in weight management & metabolic regulation.

Metformin

500mg

Intermittent Fasting

0mg

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