StackTerminal.Health

BETA

L-Leucine

L-Leucine is an essential branched-chain amino acid that plays a critical role in muscle protein synthesis, particularly beneficial for muscle growth and recovery in athletes, the elderly, and those on plant-based diets.

muscle-growthstrengthrecoveryanti-agingnutritional
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Lean / Muscle Mass
Performance
Muscle Strength (1RM)
Evidence
3 records
anemia improvement
patients with transfusion-dependent Diamond-Blackfan anemiaCohort
PUBMEDLow

L-leucine improved anemia and growth in patients with Diamond-Blackfan anemia.

Dose: 3000 mgDuration: Phase I/II studyForm: Free-form
quality of life improvement
patients with Niemann-Pick disease type CRCT
PUBMEDModerate

N-acetyl-L-leucine improved symptoms and quality of life in Niemann-Pick disease type C patients.

Dose: 4000 mgDuration: 6 weeksForm: N-acetyl-L-leucine
muscle protein synthesis
untrained midlife womenRCT
PUBMEDModerate

L-leucine supplementation coupled with resistance training improved muscle protein synthesis.

Dose: 3000 mgDuration: 12 weeksForm: Free-form
Forms
Free-form
Commonly used in supplements for direct ingestion.
N-acetyl-L-leucine
A modified form used in specific clinical settings.

Stacks containing L-Leucine

Public community stacks that include this ingredient.

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performancemuscle-growthstrength

Combining Ecdysterone with Leucine can enhance athletic performance and support muscle growth. Ecdysterone is an anabolic agent that promotes muscle growth, while Leucine is a key amino acid for muscle protein synthesis.

Ecdysterone (Beta-Ecdysterone)
500mg
L-Leucine
3000mg
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