Bromelain

Bromelain is a pineapple-derived enzyme known for its anti-inflammatory & fibrinolytic properties, often used for osteoarthritis, sinusitis, wound healing, & sports injury recovery.

anti-inflammatoryrecoveryjoint-healthimmune

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Inflammation

IL-6TNF-αCRP (Inflammation)

Evidence

4 records

Inflammation reduction

Adults with inflammatory conditions • Systematic review

PUBMEDModerate

Bromelain reduced IL-1β, IL-6, & TNF-α secretion in immune cells.

Dose: 500 mg

Citation: Alves Nobre et al. (2025). Bromelain as a natural anti-inflammatory drug: a systematic review.

Postoperative healing

Patients undergoing breast conservative surgery • RCT

PUBMEDModerate

Bromelain reduced pain, edema, & inflammation, aiding postoperative healing.

Dose: 500 mg

Citation: Sgaramella et al. (2025). Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery.

Tendon healing

Adults with tendinopathy • Systematic review

PUBMEDLow

Bromelain showed potential in reducing inflammation & improving tendon healing.

Dose: 500 mg

Citation: Pereira et al. (2023). Bromelain supplementation and inflammatory markers: A systematic review of clinical trials.

Pain & swelling reduction

Patients post third molar surgery • RCT

PUBMEDModerate

Bromelain reduced pain, swelling, & trismus compared to placebo.

Dose: 500 mgDuration: 7 daysForm: Lyophilized pineapple extractTiming: Initiated on the day of surgery

Citation: Mendes et al. (2019). Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery.

Forms

Capsule

Commonly used for standardized dosing.

Tablet

Available in various dosages for oral consumption.

Powder

Can be mixed with liquids for easier ingestion.

Stacks containing Bromelain

Public community stacks that include this ingredient.

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jointinflammationrecovery

Joint Health & Inflammation Reduction

by@athlete

Boswellia & bromelain are combined to support joint health & reduce inflammation. Boswellia has anti-inflammatory properties, while bromelain aids in reducing swelling & improving joint function.

Boswellia Serrata

300mg

Bromelain

500mg

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