Berberine HCl
Berberine HCl is a hydrochloride salt form of berberine that improves solubility & is known for its AMPK-activating mechanism, showing evidence for glycemic control, lipid profiles, & metabolic syndrome management.
Evidence last reviewed: 05 Apr 2026
Berberine HCl is a supplement that may help improve metabolic health. It shows promise for glycemic control and lipid profiles, but results can vary.
Summarized study outcomes with population, design, grade, and effect data.
Moderate evidence supports berberine HCl's role in improving lipid profiles and insulin sensitivity in adults with metabolic syndrome and type 2 diabetes. However, the evidence for glycemic control in prediabetic adults is limited and requires further investigation.
Glycemic controlPrediabetic adults · RCTLow
The study aims to evaluate the efficacy of a polyherbal dietary supplement on glycemic parameters in prediabetic adults.
Lipid profile improvementAdults with metabolic syndrome · RCTModerate
Berberine HCl supplementation improved lipid profiles in adults with metabolic syndrome.
Improved insulin sensitivityAdults with type 2 diabetes · RCTModerate
Berberine HCl improved insulin sensitivity in adults with type 2 diabetes.
Stacks containing Berberine HCl
Public community stacks that include this ingredient.
Metabolic Health Enhancement
This stack combines berberine-hcl & chromium-picolinate to enhance metabolic health & regulate blood sugar levels. Berberine has been shown to improve insulin sensitivity, while chromium-picolinate supports glucose metabolism.