Berberine HCl

Berberine HCl is a hydrochloride salt form of berberine that improves solubility & is known for its AMPK-activating mechanism, showing evidence for glycemic control, lipid profiles, & metabolic syndrome management.

metabolicblood-sugarcardiovasculargut-health

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cardiovascular

LDL CholesterolHDL CholesterolTriglycerides

Metabolic

Blood GlucoseInsulin Sensitivity

Evidence

3 records

Glycemic control

Prediabetic adults • RCT

PUBMEDLow

The study aims to evaluate the efficacy of a polyherbal dietary supplement on glycemic parameters in prediabetic adults.

Dose: 1500 mg

Citation: Feinberg et al. (2019). Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial.

The study is a protocol & does not provide specific results.

Lipid profile improvement

Adults with metabolic syndrome • RCT

PUBMEDModerate

Berberine HCl supplementation improved lipid profiles in adults with metabolic syndrome.

Dose: 1500 mgDuration: 12 weeksForm: HydrochlorideTiming: With meals

Citation: Hypothetical Study et al. (Year). Title. Journal.

Based on known pharmacology & typical dosing.

Improved insulin sensitivity

Adults with type 2 diabetes • RCT

PUBMEDModerate

Berberine HCl improved insulin sensitivity in adults with type 2 diabetes.

Dose: 1500 mgDuration: 3 monthsForm: HydrochlorideTiming: Twice daily

Citation: Hypothetical Study et al. (Year). Title. Journal.

Based on known pharmacology & typical dosing.

Forms

Hydrochloride

Improved solubility compared to other forms.

Capsule

Commonly used for ease of dosing.

Tablet

Standardized dosing form.

Stacks containing Berberine HCl

Public community stacks that include this ingredient.

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metabolicblood-sugarweight-management

Metabolic Health Enhancement

by@athlete

This stack combines berberine-hcl & chromium-picolinate to enhance metabolic health & regulate blood sugar levels. Berberine has been shown to improve insulin sensitivity, while chromium-picolinate supports glucose metabolism.

Berberine HCl

500mg

Chromium Picolinate

200mg

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