Zoloft (Sertraline)
Zoloft is a widely prescribed SSRI used to treat depression, PTSD, OCD, panic disorder, & social anxiety, making it a first-line treatment for many anxiety & depressive disorders.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
The evidence supporting Zoloft is robust, particularly for depression, panic disorder, and relapse prevention. While it shows moderate effectiveness for OCD and PTSD, further research is needed to explore its long-term impacts and combination therapies.
Depression relapse preventionAdults with major depressive disorder · Systematic reviewHigh
Sertraline was effective in preventing relapse in the maintenance phase of major depressive disorder.
PTSD symptom improvementAdults with PTSD · RCTModerate
Sertraline, in combination with brexpiprazole, significantly improved PTSD symptoms compared to sertraline alone.
OCD symptom reductionChildren and adolescents with OCD · RCTModerate
Sertraline, alone or in combination with cognitive-behavioral therapy, was effective in reducing OCD symptoms.
Panic disorder treatmentAdults with panic disorder with or without agoraphobia · Systematic reviewHigh
Sertraline was found to be effective in treating panic disorder, with a favorable safety profile.
Depression treatment in adolescentsAdolescents with depression · Systematic reviewHigh
Sertraline was effective in treating depression in adolescents, with a good tolerability profile.