Yohimbine
Yohimbine is an alpha-2 adrenergic receptor antagonist derived from the bark of the Pausinystalia yohimbe tree, known for increasing norepinephrine release and facilitating fat mobilization, particularly effective in a fasted state. It is used for fat loss and has potential benefits for sexual health, but may cause side effects like anxiety and hypertension at higher doses.
Evidence last reviewed: 20 Apr 2026
Moderate evidence supports yohimbine's role in fat mobilization and erectile dysfunction improvement. However, anxiety as a side effect is noted, particularly at higher doses, indicating the need for careful dosing.
Fat mobilizationAthletes · Systematic reviewModerate
Yohimbine is suggested to aid in fat mobilization, particularly in a fasted state, enhancing fat loss in athletes.
Erectile dysfunctionMen with erectile dysfunction · Systematic review and meta-analysisModerate
Yohimbine has been shown to improve erectile function in men with erectile dysfunction.
AnxietyGeneral population · Systematic reviewLow
Yohimbine may increase anxiety levels, particularly at higher doses.
Forms & usage▾
Take 5-10 mg before meals or workouts, ideally in a fasted state.