Wellbutrin (Bupropion)
Wellbutrin is a dopamine-norepinephrine reuptake inhibitor approved for treating depression & aiding smoking cessation. It is also used off-label for ADHD & weight management.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
The evidence supports Wellbutrin's effectiveness for major depressive disorder and smoking cessation, with moderate to high quality studies backing its use. However, its efficacy for ADHD is less robust, and further research is needed to fully understand its weight management potential.
ADHD symptom managementAdults with ADHD · Systematic reviewLow
Bupropion showed improvement in clinical response for ADHD symptoms compared to placebo.
Smoking cessationSmokers with and without psychiatric disorders · RCTHigh
Bupropion, when combined with behavioral counseling, significantly increased quit rates compared to usual care.
Weight managementAdults with obesity · Systematic reviewModerate
Naltrexone-bupropion was effective in regulating appetite & contributing to weight loss.
Major depressive disorderPatients with major depressive disorder · RCTModerate
AXS-05 (dextromethorphan-bupropion) showed significant improvement in depression symptoms compared to placebo.