Vitamin B6 (Pyridoxine)
Essential coenzyme involved in neurotransmitter synthesis, amino acid metabolism, & immune function.
Evidence last reviewed: 04 Apr 2026
- •those with neuropathy or nerve damage
- •individuals on certain medications
- •pregnant women without medical advice
Research shows moderate evidence for Vitamin B6's effectiveness in improving PMS mood symptoms and providing a modest antidepressant effect when combined with magnesium. However, more studies are needed to fully understand its benefits and optimal dosing.
PMS symptoms / moodWomen with PMS; adults with depression · RCTsModerate
Consistent improvement in PMS mood symptoms; modest antidepressant signal when combined with magnesium.
Forms & usage▾
Take 1.3 to 2.0 mg daily, preferably in the P5P form, with food.
Safety & trade-offs2▾
Peripheral neuropathy (tingling/numbness in hands and feet) with sustained high doses
Context: doses >100mg/day for months
Pyridoxine HCl form associated with higher neuropathy risk — P5P (active) form better tolerated at therapeutic doses
●High ●Moderate ● Low / note