StackTerminal.Health

BETA

Vitamin B-Complex

Bundle of B vitamins; evidence depends on formulation & baseline deficiency. Some RCTs report improved fatigue/exercise outcomes with specific products.

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Evidence last reviewed: 04 Apr 2026

Evidence
2 records
2 recordsBest grade:High
Biomarkers
Muscle EnduranceHomocysteine

The evidence shows that B vitamin supplementation can lower homocysteine levels, which may benefit cardiovascular health, but the impact on fatigue and exercise endurance is less clear and based on limited studies. More research is needed to confirm these benefits across different populations.

Homocysteine lowering & cardiovascular outcomes
Adults at increased cardiovascular risk · Meta-analysis of RCTs
High

Meta-analysis of 8 RCTs (n=37,485) found that B vitamin supplementation reduced homocysteine by ~25% but had no significant effect on major cardiovascular events, stroke, cancer, or total mortality. Routine B vitamin supplementation for CVD prevention is not supported.

Dose: 0 mgDuration: Median 5 years
Fatigue / exercise endurance markers
General adults (not athletes) · RCT
Low

A placebo-controlled trial reported improved fatigue-related biomarkers & endurance outcomes after 28 days with a specific B-complex formulation.

Dose: 10 mgDuration: 28 daysForm: Ex PLUS
Stacks containing Vitamin B-Complex
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strengthrecoverydaily

This tailored supplement stack is optimized for enhancing strength, recovery, and joint health during your active recovery week. The combination of magnesium, ashwagandha, sodium hyaluronate, vitamin B-complex, and tart cherry supports muscle relaxation, reduces inflammation, and promotes overall longevity, ensuring you bounce back stronger from your high training load.

Magnesium (Glycinate)
300mg
Ashwagandha
300mg
Sodium Hyaluronate
150mg
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My Sample Stack

by@tin_man140_6

Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.

Vitamin B-Complex
26mg
Vitamin C
500mg
Ashwagandha
600mg
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Community Insights
Forms & usage
How to take it

Take as directed on the label, typically once daily with food.

Capsule / tablet
Formulations vary widely
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