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Vinpocetine

Vinpocetine is a semi-synthetic derivative of vincamine that may enhance cerebral blood flow & cognitive function, particularly in individuals with cognitive impairments or neurological conditions.

cognitivememoryneuroprotectioncardiovascular

Evidence last reviewed: 05 Apr 2026

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Evidence
8 records
8 recordsBest grade:Moderate
Biomarkers
Cognitive FunctionNeuroprotection / NGFTNF-α

The evidence for vinpocetine is moderate, showing some potential for neuroprotection in stroke patients but no significant cognitive benefits in healthy individuals or those with epilepsy. Gaps include a lack of strong evidence for cognitive enhancement and limited studies on long-term effects.

Cognitive function
Healthy adult volunteers · RCT
Moderate

No significant cognitive benefits were observed in healthy volunteers.

Dose: 20 mgDuration: Single doseForm: Oral
Citation: Perng et al. (2018). The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis. Psychopharmacology.
Neuroprotection
Acute ischemic stroke patients · Systematic review and Meta-analysis
Moderate

Vinpocetine was well tolerated but not associated with positive cognitive effects in stroke patients.

Dose: 20 mg
Citation: Panda et al. (2022). Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Neurocritical Care.
Higher dosages may be needed to assess efficacy.
Cognitive function
Patients with epilepsy · RCT
Moderate

No significant cognitive benefits were observed in patients with epilepsy.

Dose: 20 mgDuration: One monthForm: Oral
Citation: Meador et al. (2021). Vinpocetine, cognition, and epilepsy. Epilepsy & Behavior.
Inflammation
Acute ischemic stroke patients · RCT
Low

Vinpocetine inhibits NF-κB-dependent inflammation in stroke patients.

Dose: 20 mg
Citation: Zhang et al. (2018). Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients. BMJ.
Inflammation
Acute ischemic stroke patients · RCT
Low

Vinpocetine inhibits NF-κB-dependent inflammation in stroke patients.

Dose: 20 mg
Citation: Zhang et al. (2018). Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients. BMJ.
Cognitive function
Healthy adult volunteers · RCT
Moderate

No significant cognitive benefits were observed in healthy volunteers.

Dose: 20 mgDuration: Single doseForm: Oral
Citation: Perng et al. (2018). The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis. Journal of Psychopharmacology.
Cognitive function
Patients with epilepsy · RCT
Moderate

No significant cognitive benefits were observed in patients with epilepsy.

Dose: 20 mgDuration: One monthForm: Oral
Citation: Meador et al. (2021). Vinpocetine, cognition, and epilepsy. Epilepsy & Behavior.
Neuroprotection
Acute ischemic stroke patients · Systematic review and Meta-analysis
Moderate

Vinpocetine was well tolerated but not associated with positive cognitive effects in stroke patients.

Dose: 20 mg
Citation: Panda et al. (2022). Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Neurocritical Care.
Higher dosages may be needed to assess efficacy.
Stacks containing Vinpocetine
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cognitivememoryfocus

Cognitive Memory Enhancement

by@athlete

Piracetam & vinpocetine are combined to enhance cognitive function & memory. Piracetam is known for its neuroprotective effects, while vinpocetine improves cerebral blood flow & cognitive performance.

Piracetam
2400mg
Vinpocetine
10mg
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Forms & usage▾
How to take it

Take 5-10 mg daily, ideally with food.

Tablet
Commonly available in 5 mg and 10 mg doses.
Capsule
Available in various dosages for oral administration.
Extended-release
Designed for prolonged effect, often used in clinical settings.
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