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BETA

Theacrine

Purine alkaloid structurally related to caffeine; found in Camellia kucha tea; marketed for energy & focus with less tolerance development than caffeine.

focusalertnessenergy

Evidence last reviewed: 04 Apr 2026

Evidence
2 records
2 recordsBest grade:Low
Biomarkers
Focus / AttentionReaction TimeCognitive Function

Current evidence suggests theacrine may improve cognitive performance and subjective feelings of energy and focus, particularly when combined with caffeine. However, the studies have small sample sizes and low strength, indicating a need for more rigorous research.

Subjective energy, alertness, & focus
Healthy young adults (n=20) · RCT (double-blind, crossover)
Low

Trends for higher self-reported attentiveness, alertness, focus, & energy with theacrine-containing supplement vs. caffeine & placebo; no significant differences on objective cognitive tests (trail making, digit symbol, reaction time).

Dose: 300 mgDuration: Acute (single dose)
Small sample (n=20); self-reported outcomes more positive than objective measures. Tolerance-resistance claim lacks human RCT confirmation.
Cognitive performance & reaction time (combined with caffeine)
Male e-gamers (n=50) · RCT (randomized crossover)
Low

Caffeine (125 mg) + TeaCrine (50 mg) + Dynamine (75 mg) combination improved Flanker inhibitory control & Psychomotor Vigilance Task reaction time vs. placebo; theacrine's isolated contribution is unclear.

Dose: 50 mgDuration: Acute
Most human evidence uses combination formulas; isolated theacrine RCTs remain limited.
Stacks containing Theacrine
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focus

Supports alertness with lower jitter risk than caffeine.

Theacrine
100mg
L-Theanine
200mg
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Forms & usage
How to take it

Take 50 mg of theacrine once daily, ideally 30 minutes before activities requiring focus.

TeaCrine® (standardized theacrine)
Patented form; used in most human studies.
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