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Sulbutiamine

Sulbutiamine is a synthetic derivative of thiamine that crosses the blood-brain barrier more effectively, potentially improving memory and reducing fatigue, particularly in conditions like multiple sclerosis and post-infectious asthenia.

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Evidence last reviewed: 20 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
Mood / WellbeingCognitive Function

Current research suggests sulbutiamine may improve cognitive performance and alleviate fatigue, particularly in specific populations. However, the overall evidence quality is low to moderate, indicating a need for further studies to confirm its efficacy.

Psycho-behavioral inhibition reduction
Patients with major depressive episodes · RCT
Moderate

Sulbutiamine was found to reduce psycho-behavioral inhibition in patients with major depressive episodes when used alongside clomipramine.

Dose: 600 mgDuration: 8 weeksForm: Arcalion
Citation: Ollat et al. (2007). Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease.
Study involved combination therapy with clomipramine.
Fatigue reduction
Patients with chronic postinfectious fatigue · RCT
Moderate

Patients treated with sulbutiamine reported significantly less incapacitation in social, professional, and family life compared to placebo.

Dose: 400 mgDuration: 4 weeks
Citation: Tiev et al. (1999). Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo.
Cognitive performance
General population · RCT
Low

Sulbutiamine may improve cognitive performance and reduce fatigue, although evidence is preliminary.

Dose: 400 mgDuration: 4 weeksForm: Arcalion
Citation: Lôo et al. (2000). Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes.
Study focused on psycho-behavioral inhibition.
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Forms & usage▾
How to take it

Take 200-600 mg daily, ideally in the morning.

Tablet
Commonly available in 200 mg tablets.
Capsule
Available in various dosages, often combined with other nootropics.
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