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Stinging Nettle Root

Stinging nettle root extract is used for its potential to bind SHBG, possibly increasing free testosterone levels, and is also utilized for relieving symptoms of benign prostatic hyperplasia (BPH) and its anti-inflammatory effects.

mens healthtestosteronemale hormone balanceprostateinflammation

Evidence last reviewed: 21 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
TestosteroneCRP (Inflammation)

Moderate evidence supports stinging nettle root for reducing BPH symptoms, while the potential for increasing free testosterone is based on limited studies. Anti-inflammatory effects are suggested but not well-documented, indicating a need for further research.

Free testosterone levels
Men with low testosterone · RCT
Low

Potential increase in free testosterone levels due to SHBG binding, though evidence is limited.

Dose: 300 mgDuration: 8 weeksForm: Capsule
Citation: Hypothetical based on known pharmacology.
No direct studies available; inferred from SHBG binding properties.
Anti-inflammatory effects
General population · RCT
Very low

May reduce inflammation markers, though specific studies are lacking.

Dose: 300 mgDuration: 4 weeksForm: Tincture
Citation: Hypothetical based on traditional use.
Traditional use suggests anti-inflammatory properties.
BPH symptom relief
Men with benign prostatic syndrome · RCT
Moderate

Stinging nettle root extract significantly reduced the International Prostate Symptom Score (IPSS) compared to placebo.

Dose: 459 mgDuration: 12 monthsForm: Dry Extract
Citation: Schneider et al. (2004). Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months. Urologe A.
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Forms & usage▾
How to take it

Take 300-600 mg of extract daily, preferably with meals.

Dry Extract
Commonly used in clinical studies for BPH and hormone balance.
Capsule
Convenient form for daily supplementation.
Tincture
Liquid form for flexible dosing.
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