The evidence for spermidine's effects on memory and cognitive function is mixed, with some studies showing moderate enhancements while others report no significant changes. The overall strength of the evidence is low to moderate, indicating a need for further research to clarify its benefits.
Cognitive functionOlder adults with subjective cognitive decline · RCTModerate
Memory performance was moderately enhanced in the spermidine group compared with placebo.
Memory performanceOlder adults at risk for Alzheimer's disease · RCTLow
Spermidine supplementation showed potential to prevent memory loss in aging model organisms, with preliminary human data supporting memory benefits.
Memory performanceOlder adults with subjective cognitive decline · RCTModerate
No significant changes in mnemonic discrimination performance were observed, but exploratory analyses suggested possible benefits on verbal memory.
Memory performanceOlder adults at risk for dementia · RCTModerate
Spermidine supplementation did not modify memory & biomarkers compared with placebo, but exploratory analyses indicated possible beneficial effects on verbal memory & inflammation.
Forms & usage▾
Take 1-2 capsules daily with food for best absorption.