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Soy Isoflavones

May reduce menopausal hot flash frequency/severity with small average effect; evidence is mixed & response varies.

womens healthmenopauselongevitymetabolic health

Evidence last reviewed: 04 Apr 2026

Evidence
2 records
2 recordsBest grade:Moderate

The evidence on soy isoflavones shows a modest reduction in hot flash frequency among peri- and postmenopausal women, with a meta-analysis indicating a maximum reduction of 25%. However, results are mixed, and individual responses can vary significantly, highlighting the need for personalized approaches.

Hot flash frequency/severity
Peri-/postmenopausal women · Evidence synthesis / clinical summary
Low

Soy isoflavone supplements or soy protein may reduce hot flashes, but average effect is small & results are not fully consistent.

Dose: 50 mgDuration: 6–12 weeks (typical study windows)
Hot flash frequency reduction — quantitative meta-analysis
Peri-/postmenopausal women · Meta-analysis of RCTs
Moderate

Model-based meta-analysis of 16 RCTs (~1,710 subjects) found soy isoflavones reduced hot flash frequency by a maximal 25.2% over placebo — a statistically real but modest effect compared to estradiol, with slow onset over several weeks.

Dose: 54 mgDuration: Varies (pooled across trials)
Stacks containing Soy Isoflavones
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hormonalwomens-healthmenopause

Red clover isoflavones & soy isoflavones are combined to support hormonal balance & alleviate menopause symptoms. Both ingredients provide phytoestrogens that can help balance hormone levels & reduce menopause-related symptoms.

Red Clover Isoflavones
40mg
Soy Isoflavones
40mg
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How to take it

Take 50-150 mg of soy isoflavones daily, preferably with food.

Capsule
Also achievable via soy foods
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