Saffron (Crocus sativus)
Saffron is a spice-derived supplement known for its antidepressant properties, showing comparable efficacy to SSRIs for mild-to-moderate depression with fewer side effects. It is also studied for its effects on PMS, memory, and appetite.
Evidence last reviewed: 20 Apr 2026
Saffron has strong evidence for reducing depressive symptoms and moderate evidence for anxiety relief, with a favorable safety profile. However, its neuroprotective effects and benefits for ADHD require further investigation.
Depression symptomsAdults with mild to moderate depression · Meta-analysisHigh
Saffron was found to be as effective as SSRIs in reducing depressive symptoms with fewer adverse events.
ADHD symptomsChildren and adolescents with ADHD · Systematic reviewLow
Saffron demonstrated promise in improving ADHD symptoms with an acceptable safety profile.
NeuroprotectionGeneral population · Systematic reviewVery low
Saffron has potential neuroprotective effects, though more research is needed to confirm these findings.
Anxiety symptomsAdults with anxiety · Meta-analysisModerate
Saffron showed a nonsignificant difference compared to SSRIs in reducing anxiety symptoms but had fewer adverse events.
Mood and Anxiety Support
Combining Kanna and Saffron can provide mood enhancement and anxiety reduction. Kanna is known for its anxiolytic and mood-enhancing properties, while Saffron has been shown to improve mood and reduce symptoms of anxiety.
Forms & usage▾
Take 30 mg of saffron extract daily, preferably with food.