Prozac (Fluoxetine)
Prozac is an SSRI antidepressant used to treat depression, OCD, panic disorder, bulimia, & PMDD, with a favorable safety profile & long half-life.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Fluoxetine has strong evidence for preventing depression relapse and treating adolescent depression, with moderate support for bulimia and eating disorders. However, its efficacy in impulse control disorders is less established, indicating a need for further research.
Bulimia symptom reductionAdults with bulimia nervosa · Systematic reviewModerate
Fluoxetine was found to be efficacious in reducing symptoms of bulimia nervosa.
Impulse control disorder managementAdults with impulse control disorders · Systematic reviewLow
Fluoxetine was one of the most efficacious treatments for impulse control disorders.
Depression relapse preventionAdults with major depressive disorder · Systematic reviewHigh
Fluoxetine was effective in preventing relapse in the maintenance phase of major depressive disorder.
Depressive symptoms in eating disordersAdults with eating disorders · Systematic reviewModerate
Fluoxetine was moderately effective in reducing depressive symptoms in eating disorders.
Adolescent depression treatmentAdolescents with depression · RCTHigh
Fluoxetine was effective in treating depression in adolescents.