Propranolol
Propranolol is a non-selective beta-blocker used primarily for cardiovascular conditions & anxiety, including performance anxiety & PTSD reconsolidation.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Propranolol has strong evidence supporting its effectiveness in reducing performance anxiety and mortality after myocardial infarction. While it is also used for preventing variceal bleeding, the evidence is moderate, indicating a need for further research in some areas.
Performance anxiety reductionAdults with performance anxiety · Systematic reviewHigh
Propranolol was effective in reducing performance anxiety symptoms.
Prevention of variceal bleedingPatients with cirrhosis · ReviewModerate
Propranolol is used as a first-line therapy to prevent variceal bleeding in cirrhosis.
Reduction in mortality post-myocardial infarctionPatients with acute myocardial infarction · RCTHigh
Propranolol significantly reduced mortality in patients post-myocardial infarction.
Reduction in symptoms of akathisiaPatients with antipsychotic-induced akathisia · Systematic reviewModerate
Propranolol was associated with a reduction in akathisia symptoms compared to placebo.